Tennen D G, Keates R H
University of California, Irvine, USA.
Curr Opin Ophthalmol. 1995 Feb;6(1):59-61.
Collagen shields are an appealing route of drug administration because they avoid complications associated with periocular injections and frequent topical drug application. A review of past studies establishes the capability of collagen shields to reach therapeutic aqueous drug levels in animal models. More recent studies on human subjects reaffirm the capability of collagen shields to provide adequate prophylaxis against the most common pathogens of postoperative endophthalmitis. Research on the use of collagen shields after routine cataract surgery shows that patients receiving the collagen shields had less postoperative anterior chamber reaction, less corneal edema, and fewer subconjunctival hemorrhages when compared with patients receiving the same medication through subconjunctival injection. Collagen shields may also be useful as a means to deliver other medications such as antivirals, antifungals, and immunosuppressive agents.
胶原盾是一种颇具吸引力的给药途径，因为它们避免了与眼周注射及频繁局部用药相关的并发症。对过往研究的回顾证实了胶原盾在动物模型中达到治疗性房水药物浓度的能力。近期针对人类受试者的研究再次肯定了胶原盾对术后眼内炎最常见病原体提供充分预防的能力。常规白内障手术后使用胶原盾的研究表明，与通过结膜下注射接受相同药物的患者相比，接受胶原盾的患者术后前房反应更少、角膜水肿更少且结膜下出血更少。胶原盾还可用作递送其他药物（如抗病毒药、抗真菌药和免疫抑制剂）的一种手段。
