Menchini U, Lanzetta P, Ferrari E, Soldano F, Vita S
Department of Ophthalmology, University of Udine, Italy.
Eur J Ophthalmol. 1994 Jul-Sep;4(3):175-80. doi: 10.1177/112067219400400307.
The efficacy of presoaked porcine collagen shields was compared with subconjunctivally injected corticosteroids and antibiotics in reducing ocular inflammation after ECCE with IOL implantation, and signs of reduced oxygen delivery to the cornea were assessed. Fifty eyes of fifty patients were recruited. At the end of surgery 25 eyes (group 1) received a 24-h shield presoaked with 0.1% betamethasone disodium phosphate and 0.5% netilmycin. The other 25 eyes (group 2) received 1 mg betamethasone disodium phosphate and 250 mg piperacillin as a subconjunctival injection. The eyes were then taped closed. Inflammatory parameters (anterior chamber flare, fibrin, folds of Descemet's membrane, corneal edema) and tolerability of the delivery system (pain, itching) were evaluated 24 h after surgery. None of the patients lost the shield and the collagen devices were well tolerated. Groups 1 and 2 showed no significant differences in the parameters considered. There was, however, transient, slight diffuse superficial corneal edema in 24% of group 1 and 4% of group 2, raising the question of inadequate oxygen transmission through collagen shields under closed lids. The results suggest that collagen shields used with the right solution have no significant adverse effect and may be a less invasive alternative to subconjunctival injection.
在白内障囊外摘除联合人工晶状体植入术后，比较预浸泡猪胶原盾与结膜下注射皮质类固醇和抗生素在减轻眼部炎症方面的效果，并评估角膜氧输送减少的迹象。招募了50名患者的50只眼睛。手术结束时，25只眼睛（第1组）接受了预先浸泡有0.1%磷酸倍他米松二钠和0.5%奈替米星的24小时胶原盾。另外25只眼睛（第2组）接受了1毫克磷酸倍他米松二钠和250毫克哌拉西林的结膜下注射。然后将眼睛包扎闭合。术后24小时评估炎症参数（前房闪光、纤维蛋白、Descemet膜皱襞、角膜水肿）和给药系统的耐受性（疼痛、瘙痒）。没有患者丢失胶原盾，且胶原装置耐受性良好。第1组和第2组在所考虑的参数方面没有显著差异。然而，第1组有24%的患者出现短暂、轻微的弥漫性浅层角膜水肿，第2组为4%，这引发了在眼睑闭合情况下通过胶原盾的氧传输不足的问题。结果表明，与合适溶液一起使用的胶原盾没有显著的不良反应，可能是结膜下注射的一种侵入性较小的替代方法。
