Dunne D W, Quagliarello V
Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut 06510.
Medicine (Baltimore). 1993 Jan;72(1):1-10. doi: 10.1097/00005792-199301000-00001.
Group B streptococcal (GBS) meningitis is a frequent entity in neonates but an uncommon cause of meningitis in adults. Retrospective analysis at our institution identified 4 adult cases over the last 25 years; an additional 46 cases from the literature were reviewed. A bimodal age distribution paralleling that seen in other severe GBS infections was observed. Clinical presentation was not unlike meningitis due to other pyogenic organisms, although a higher percentage of patients presented with less than 24 hours of symptoms. Forty-three percent of patients had no underlying illnesses. Concomitant bacteremia was present in 83% of patients. The overall mortality was 27% and was limited exclusively to patients with co-morbid illnesses. Meningitis in adults due to GBS should be considered in the immunocompetent as well as the immunocompromised host.
B族链球菌（GBS）脑膜炎在新生儿中很常见，但在成人中却是脑膜炎的罕见病因。我们机构的回顾性分析在过去25年中发现了4例成人病例；还对文献中的另外46例病例进行了回顾。观察到年龄分布呈双峰型，与其他严重GBS感染所见相似。临床表现与其他化脓性微生物引起的脑膜炎无异，尽管有更高比例的患者症状出现时间少于24小时。43%的患者没有基础疾病。83%的患者伴有菌血症。总体死亡率为27%，且仅局限于有合并症的患者。在免疫功能正常以及免疫功能低下的宿主中，均应考虑成人GBS引起的脑膜炎。
