Blair A, Linos A, Stewart P A, Burmeister L F, Gibson R, Everett G, Schuman L, Cantor K P
Environmental Epidemiology Branch, National Cancer Institute, Rockville, Maryland 20892.
Am J Ind Med. 1993 Feb;23(2):301-12. doi: 10.1002/ajim.4700230207.
The etiology of non-Hodgkin's lymphoma (NHL) is not well understood. To develop hypotheses on causes of this tumor, data from a population-based case-control interview study of 1,867 white men (622 cases and 1,245 controls) in Iowa and Minnesota conducted during 1980-1983 were examined. Subjects, or their next of kin, were interviewed to obtain information on agricultural exposures, work history, medical conditions, and family history. This analysis focuses on risks of NHL by occupation, by industry, and by selected exposures. Although many comparisons were made, few significant associations were observed. Small numbers and limitations in exposure assessment, however, would tend to reduce opportunities to detect associations. The strongest finding was with various occupations that work in metals and metal products. The analysis by exposure estimates also uncovered a significant association with metals, but risks did not increase with estimated intensity of exposure. Slightly elevated risks were also noted among persons employed as painters and construction workers, agricultural and forestry workers, printers and typesetters, funeral directors and embalmers, and dry cleaners. Although the overall risks for benzene and other solvents were small, they increased slightly with level of assigned exposure. Although some associations may be due to chance, several of these occupations and industries have been linked to lymphoma in other investigations and deserve further attention.
非霍奇金淋巴瘤（NHL）的病因尚未完全明确。为了对这种肿瘤的病因提出假设，我们研究了1980年至1983年期间在爱荷华州和明尼苏达州对1867名白人男性（622例病例和1245名对照）进行的一项基于人群的病例对照访谈研究的数据。对受试者或其近亲进行访谈，以获取有关农业接触、工作史、医疗状况和家族史的信息。本分析重点关注按职业、行业和选定接触因素划分的NHL风险。尽管进行了许多比较，但观察到的显著关联很少。然而，样本量较小以及接触评估存在局限性，往往会减少发现关联的机会。最显著的发现是与从事金属和金属制品工作的各种职业有关。通过接触估计进行的分析还发现与金属存在显著关联，但风险并未随着估计接触强度的增加而增加。油漆工、建筑工人、农业和林业工人、印刷工和排版工、殡仪员和防腐师以及干洗工的风险也略有升高。尽管苯和其他溶剂的总体风险较小，但它们随着指定接触水平的升高而略有增加。虽然一些关联可能是偶然的，但这些职业和行业中的一些在其他调查中已与淋巴瘤相关联，值得进一步关注。
