Shirouzu K, Isomoto H, Kakegawa T
First Department of Surgery, Kurume University School of Medicine, Japan.
Am J Surg. 1993 Feb;165(2):233-7. doi: 10.1016/s0002-9610(05)80517-3.
To evaluate whether perineural invasion (PNI) is an important prognostic factor in patients with rectal cancer, we reviewed the records of 373 patients who underwent curative surgery. Thirty-seven patients (9.9%) were identified as having tumors with PNI. The incidence of PNI was significantly increased in lesions categorized as stage III by the International Union Against Cancer (UICC) system (20%). There was a significant difference in local recurrence between patients with stage III lesions with PNI and those with stage III lesions without PNI (p < 0.005). Also, patients with PNI of stage III lesions had a significantly lower 8-year survival rate (26.7%, p < 0.001). We conclude that PNI is an important factor influencing the prognosis of patients with stage III disease. PNI should be classified as a subgroup of the clinical stage.
为评估神经周围浸润（PNI）是否为直肠癌患者的重要预后因素，我们回顾了373例行根治性手术患者的病历。37例（9.9%）患者被确定为肿瘤伴有PNI。国际抗癌联盟（UICC）系统分类为Ⅲ期的病变中PNI发生率显著升高（20%）。Ⅲ期病变伴有PNI的患者与不伴有PNI的患者局部复发存在显著差异（p<0.005）。此外，Ⅲ期病变伴有PNI的患者8年生存率显著更低（26.7%，p<0.001）。我们得出结论，PNI是影响Ⅲ期疾病患者预后的重要因素。PNI应归类为临床分期的一个亚组。
