Taupitz M, Wagner S, Hamm B, Dienemann D, Lawaczeck R, Wolf K J
Department of Radiology, Klinikum Steglitz, Freie Universität Berlin, Germany.
Acta Radiol. 1993 Jan;34(1):10-5.
MR images of the iliac lymph nodes of 25 VX2 carcinoma-bearing rabbits and of 5 tumor-free rabbits were obtained at 1.5 T before and after endolymphatic administration of superparamagnetic iron oxide particles (SPIO) at a dose of 1 mumol Fe per extremity. Imaging results were correlated with histology. In unenhanced images intranodal metastases were not detectable with any of the pulse sequences used and the signal intensities of tumor-free and metastatic lymph nodes did not differ significantly. After administration of the contrast medium, a significant signal loss (p < or = 0.05) occurred in the healthy lymph node tissue, whereas the signal intensity of lymph node metastases remained unchanged. In SPIO enhanced images, the threshold size for detection of lymph node metastases was 2 mm. Metastatic involvement was detected in 28 of the 30 tumorous lymph nodes with the SE 2000/15 sequence but in a smaller number of lymph nodes with the sequences SE 500/22 (n = 27) and 2000/65 (n = 21).
对25只荷VX2癌兔和5只无瘤兔的髂淋巴结进行磁共振成像，在1.5T条件下，于四肢内淋巴注射剂量为1μmol铁的超顺磁性氧化铁颗粒（SPIO）前后获取图像。成像结果与组织学结果相关。在未增强图像中，使用的任何脉冲序列均无法检测到结内转移，无瘤淋巴结和转移淋巴结的信号强度无显著差异。注射造影剂后，健康淋巴结组织出现显著信号丢失（p≤0.05），而淋巴结转移灶的信号强度保持不变。在SPIO增强图像中，检测淋巴结转移的阈值大小为2mm。使用SE
