枯草芽孢杆菌中由环状前体合成ω-脂环族脂肪酸
Synthesis of omega-alicyclic fatty acids from cyclic precursors in Bacillus subtilis.
作者信息
Dreher R, Poralla K, König W A
出版信息
J Bacteriol. 1976 Sep;127(3):1136-40. doi: 10.1128/jb.127.3.1136-1140.1976.
Abstract
A mutant of Bacillus subtilis synthesizes a variety of omega-alicyclic fatty acids when fed with the respective alicyclic carboxylic acids. These fatty acids are: omega-cyclopropane, omega-cyclobutane, omega-cyclopentane, omega-cyclohexane, and omega-cyclohexene fatty acids. These unusual fatty acids did not lead to an inhibition of growth at 37 degrees C and pH 7. The selective advantage of these fatty acids under extrene conditions was studied in comparison with the acidophilic, thermophilic bacterium B. acidocaldarius, which normally contains a high proportion of omega-cyclohexane fatty acids.
摘要
枯草芽孢杆菌的一个突变体在被投喂相应的脂环族羧酸时会合成多种ω-脂环族脂肪酸。这些脂肪酸包括：ω-环丙烷、ω-环丁烷、ω-环戊烷、ω-环己烷和ω-环己烯脂肪酸。这些不同寻常的脂肪酸在37摄氏度和pH值为7的条件下不会抑制生长。与通常含有高比例ω-环己烷脂肪酸的嗜酸嗜热菌嗜酸热硫化叶菌相比，研究了这些脂肪酸在极端条件下的选择优势。
相似文献
1
Synthesis of omega-alicyclic fatty acids from cyclic precursors in Bacillus subtilis.枯草芽孢杆菌中由环状前体合成ω-脂环族脂肪酸
J Bacteriol. 1976 Sep;127(3):1136-40. doi: 10.1128/jb.127.3.1136-1140.1976.
2
The influence of branched-chain and omega-alicyclic fatty acids on the transition temperature of bacillus subtilis lipids.支链脂肪酸和ω-脂环族脂肪酸对枯草芽孢杆菌脂质转变温度的影响。
Biochim Biophys Acta. 1978 Oct 4;512(3):489-94. doi: 10.1016/0005-2736(78)90159-1.
3
4
The formation of -cyclohexyl-fatty acids from shikimate in an acidophilic thermophilic bacillus. A new biosynthetic pathway.嗜热嗜酸芽孢杆菌中莽草酸形成β-环己基脂肪酸。一条新的生物合成途径。
Biochem J. 1972 Jul;128(4):751-4. doi: 10.1042/bj1280751.
5
[GAS CHROMATOGRAPHY RETENTION DATA AND STRUCTURE OF CHEMICAL COMPOUNDS. I. ALPHA-BRANCHED ALIPHATIC AND ALICYCLIC CARBOXYLIC ACID METHYL ESTERS].
J Chromatogr. 1964 Apr;14:157-77. doi: 10.1016/s0021-9673(00)86607-8.
6
Fatty acid-requiring mutant of bacillus subtilis defective in branched chain alpha-keto acid dehydrogenase.枯草芽孢杆菌中在支链α-酮酸脱氢酶方面存在缺陷的脂肪酸需求突变体。
J Biol Chem. 1971 Sep 10;246(17):5264-72.
7
[Effect of growth decrease on the metabolism of fatty acids of Bacillus subtilis var. niger].
C R Acad Hebd Seances Acad Sci D. 1972 Jan 17;274(3):468-71.
8
Unsaturated and branched chain-fatty acids in temperature adaptation of Bacillus subtilis and Bacillus megaterium.枯草芽孢杆菌和巨大芽孢杆菌温度适应性中的不饱和脂肪酸和支链脂肪酸
Biochim Biophys Acta. 1992 Jun 22;1126(2):119-24. doi: 10.1016/0005-2760(92)90281-y.
9
Biosynthetic studies on the origin of the cyclohexanecarboxylic acid moiety of ansatrienin A and omega-cyclohexyl fatty acids.关于安莎曲菌素A和ω-环己基脂肪酸中环己烷羧酸部分起源的生物合成研究。
J Nat Prod. 1994 Mar;57(3):382-6. doi: 10.1021/np50105a008.
10
Effect of Ring Size in ω-Alicyclic Fatty Acids on the Structural and Dynamical Properties Associated with Fluidity in Lipid Bilayers.ω-脂环族脂肪酸中环大小对脂质双层流动性相关结构和动力学性质的影响。
Langmuir. 2015 Oct 27;31(42):11574-82. doi: 10.1021/acs.langmuir.5b02635. Epub 2015 Oct 14.
引用本文的文献
1
Development of cyclobutene- and cyclobutane-functionalized fatty acids with inhibitory activity against Mycobacterium tuberculosis.具有抗结核分枝杆菌抑制活性的环丁烯和环丁烷官能化脂肪酸的开发。
ChemMedChem. 2014 Aug;9(8):1838-49. doi: 10.1002/cmdc.201402067. Epub 2014 Jun 5.
2
Biosynthesis of ω-alicyclic fatty acids induced by cyclic precursors and change of membrane fluidity in thermophilic bacteria Geobacillus stearothermophilus and Meiothermus ruber.热嗜热杆菌和红景天热球菌中环前体诱导的ω-脂环酸的生物合成及膜流动性的变化。
Extremophiles. 2011 May;15(3):423-9. doi: 10.1007/s00792-011-0373-4. Epub 2011 Apr 13.
3
Sporulation in Bacillus subtilis is independent of membrane fatty acid composition.枯草芽孢杆菌中的孢子形成与膜脂肪酸组成无关。
J Bacteriol. 1981 Nov;148(2):480-6. doi: 10.1128/jb.148.2.480-486.1981.
4
Iso- and anteiso-fatty acids in bacteria: biosynthesis, function, and taxonomic significance.细菌中的异脂肪酸和反异脂肪酸：生物合成、功能及分类学意义
Microbiol Rev. 1991 Jun;55(2):288-302. doi: 10.1128/mr.55.2.288-302.1991.
5
Fatty acids of the genus Bacillus: an example of branched-chain preference.芽孢杆菌属的脂肪酸：支链偏好的一个例子。
Bacteriol Rev. 1977 Jun;41(2):391-418. doi: 10.1128/br.41.2.391-418.1977.
本文引用的文献
1
A long-chain fatty acid acyl-coA synthetase in Bacillus megaterium.
Biochim Biophys Acta. 1963 Jun 11;73:335-7. doi: 10.1016/0006-3002(63)90320-2.
2
Fatty acid-requiring mutant of bacillus subtilis defective in branched chain alpha-keto acid dehydrogenase.枯草芽孢杆菌中在支链α-酮酸脱氢酶方面存在缺陷的脂肪酸需求突变体。
J Biol Chem. 1971 Sep 10;246(17):5264-72.
3
4
Biosynthesis of branched-chain fatty acids. IV. Factors affecting relative abundance of fatty acids produced by Bacillus subtilis.支链脂肪酸的生物合成。IV. 影响枯草芽孢杆菌产生的脂肪酸相对丰度的因素。
Can J Microbiol. 1966 Jun;12(3):501-14. doi: 10.1139/m66-073.
5
Effects of pH and temperature on the fatty acid composition of bacillus acidocaldarius.pH值和温度对嗜酸热硫化叶菌脂肪酸组成的影响。
J Bacteriol. 1974 Jan;117(1):212-4. doi: 10.1128/jb.117.1.212-214.1974.
6
Biochemistry of bacterial membranes.细菌膜的生物化学
Annu Rev Biochem. 1973;42:575-600. doi: 10.1146/annurev.bi.42.070173.003043.
7
Motion of spin labeled fatty acids in membrane structures.自旋标记脂肪酸在膜结构中的运动。
Biomembranes. 1972;3:267-79. doi: 10.1007/978-1-4684-0961-1_18.
8
The chemical composition of the cytoplasmic membrane of Bacillus subtilis.枯草芽孢杆菌细胞质膜的化学成分。
Eur J Biochem. 1967 Nov;2(4):448-53. doi: 10.1111/j.1432-1033.1967.tb00158.x.
9
Genetic modification of membrane lipid.膜脂的基因修饰
Annu Rev Biochem. 1975;44:315-39. doi: 10.1146/annurev.bi.44.070175.001531.
Zotero 插件