Kertesz A, Lau W K, Polk M
Department of Clinical Neurological Sciences, St. Joseph's Health Centre, London, Ontario, Canada.
Brain Lang. 1993 Feb;44(2):153-64. doi: 10.1006/brln.1993.1010.
Recovery of comprehension and total language in 22 Wernicke's aphasics was correlated with lesion size and extent of involvement of certain structures on CT. Recovery rates and outcomes were separately examined using 0-3 months and 0-12 months poststroke language data. Quantitative measures of structural damage were regressed on total aphasia and comprehension outcome measures. Supramarginal and angular gyri appeared to be the most significant structures in recovery in addition to initial severity and lesion size. This was confirmed by using ANOVA to compare the extent of involvement in each postcentral structure among the poor, moderate, and good recovery groups. The superior temporal and middle temporal gyri are less involved in the good recovery group. Structures posteriorly adjacent to Wernicke's area are important for compensation in Wernicke's aphasia and in the accompanying comprehension deficit. Persisting Wernicke's aphasia usually involves the supramarginal and angular gyri in addition to the superior temporal area.
22例韦尼克失语症患者的语言理解和整体语言恢复情况与CT上的病灶大小及某些结构的受累范围相关。分别使用卒中后0 - 3个月和0 - 12个月的语言数据来检查恢复率和恢复结果。将结构损伤的定量测量值与整体失语症和语言理解结果测量值进行回归分析。除了初始严重程度和病灶大小外，缘上回和角回似乎是恢复过程中最重要的结构。通过方差分析比较恢复较差、中等和良好组中每个中央后结构的受累程度，证实了这一点。颞上回和颞中回在恢复良好组中的受累程度较小。与韦尼克区相邻的后部结构对于韦尼克失语症及伴随的语言理解缺陷的代偿很重要。持续性韦尼克失语症除了颞上区外，通常还涉及缘上回和角回。
