Basketter D A, Briatico-Vangosa G, Kaestner W, Lally C, Bontinck W J
ECETOC, European Chemical Industry Ecology and Toxicology Centre, Brussels.
Contact Dermatitis. 1993 Jan;28(1):15-25. doi: 10.1111/j.1600-0536.1993.tb03318.x.
In spite of the improved awareness of the potential for nickel, cobalt and chromium to cause skin allergy, the incidence of sensitization to them is generally on the increase, especially for nickel. We review data from the literature and industry on transition metal contamination of consumer products and assess the hazard to man. Consumer products are defined as personal care items and detergent/cleaning products used regularly in domestic work. The analytical data demonstrate that consumer products are a relatively minor source of contact with nickel, cobalt or chromium. The traces found in consumer products will not be the primary cause of sensitization to these metals: levels will be too low and exposure too brief. A person sensitized to these metals has many other more significant sources of daily contact such as earrings, jewelry and metal objects. It is therefore necessary to focus on decreasing the high exposure to these transition metals from other sources rather than on possible trace amounts found in consumer products. Current good manufacturing practice ensures that trace nickel, cobalt and chromium concentrations in consumer products are less than 5 ppm of each metal. It is recommended that this be accepted as a standard for maximum concentrations and that the target should be to achieve concentrations as low as 1 ppm.
尽管人们对镍、钴和铬引发皮肤过敏的可能性的认识有所提高,但对它们的致敏率总体上仍在上升,尤其是镍。我们回顾了文献和行业中关于消费品过渡金属污染的数据,并评估了对人体的危害。消费品定义为家庭日常使用的个人护理用品和洗涤剂/清洁产品。分析数据表明,消费品是接触镍、钴或铬的相对次要来源。消费品中发现的痕量不会是对这些金属致敏的主要原因:含量过低且接触时间过短。对这些金属致敏的人有许多其他更重要的日常接触来源,如耳环、珠宝和金属物品。因此,有必要专注于减少来自其他来源的对这些过渡金属的高暴露,而不是关注消费品中可能存在的痕量。当前良好生产规范确保消费品中镍、钴和铬的痕量浓度低于每种金属5 ppm。建议将此作为最大浓度标准接受,目标应是将浓度降至1 ppm。