Chollet D, Künstner P, Wermeille M
Department of Toxicology and Pharmacokinetics, Zyma SA, CH-1260, Nyon, Switzerland.
J Chromatogr. 1993 Jan 15;629(1):89-93. doi: 10.1016/0021-9673(93)80358-f.
An automated high-performance liquid chromatographic assay, using on-line solid-phase extraction, is described for the determination of dimethindene in urine. The solid-phase extraction of the sample (1000 microliters) and the elution of the drug on to the analytical column are performed automatically and concomitantly. The limit of quantification is 5 pmol/ml.
本文描述了一种采用在线固相萃取的自动高效液相色谱法，用于测定尿液中的二甲茚定。样品（1000微升）的固相萃取和药物在分析柱上的洗脱过程自动且同时进行。定量限为5皮摩尔/毫升。
