Mooij P N, Steegers-Theunissen R P, Thomas C M, Doesburg W H, Eskes T K
Department of Obstetrics and Gynecology, University Hospital, Nijmegen, The Netherlands.
J Nutr. 1993 Feb;123(2):197-203. doi: 10.1093/jn/123.2.197.
Folic acid and other vitamin deficiencies may play a role in the etiology of neural tube defects. The Medical Research Council Vitamin Study confirmed the beneficial effect of folic acid supplementation on the prevention of neural tube defects. However, the concentrations of vitamins other than folate were not a common feature of any of the former studies. We measured the concentrations of vitamin A, riboflavin, riboflavine-5'-monophosphate, flavine-adenine-dinucleotide, vitamin B-6, vitamin B-12, vitamin C, vitamin E, folate and ferritin in the serum of women who had previously had a child with a neural tube defect and were planning a further pregnancy. Vitamin and folic acid supplements were supplied before conception to 44 high risk women before conception. Eighteen other high risk women not given supplements were the control group. We concluded that vitamin profiles do not form a suitable means for identifying women at risk for neural tube defects before pregnancy. This endorses the hypothesis that the beneficial effect of folic acid supplementation on the prevention of neural tube defects is possibly at least partly due to the fact that it overrides a relative folic acid shortage caused by a metabolic disorder.
叶酸和其他维生素缺乏可能在神经管缺陷的病因中起作用。医学研究委员会维生素研究证实了补充叶酸对预防神经管缺陷的有益作用。然而，除叶酸外的其他维生素浓度并非以往任何一项研究的共同特征。我们测量了曾生育过神经管缺陷患儿且计划再次怀孕的女性血清中维生素A、核黄素、核黄素-5'-单磷酸、黄素腺嘌呤二核苷酸、维生素B-6、维生素B-12、维生素C、维生素E、叶酸和铁蛋白的浓度。在受孕前为44名高危女性提供了维生素和叶酸补充剂。另外18名未接受补充剂的高危女性作为对照组。我们得出结论，维生素谱并非识别孕前神经管缺陷高危女性的合适方法。这支持了以下假设，即补充叶酸对预防神经管缺陷的有益作用可能至少部分归因于它克服了由代谢紊乱导致的相对叶酸缺乏这一事实。
