新型胃肠外头孢菌素头孢唑兰（SCE - 2787）对小鼠实验性感染的治疗效果
Therapeutic effect of cefozopran (SCE-2787), a new parenteral cephalosporin, against experimental infections in mice.
作者信息
Iizawa Y, Okonogi K, Hayashi R, Iwahi T, Yamazaki T, Imada A
机构信息
Pharmaceutical Research Laboratories III, Takeda Chemical Industries, Osaka, Japan.
出版信息
Antimicrob Agents Chemother. 1993 Jan;37(1):100-5. doi: 10.1128/AAC.37.1.100.
The therapeutic effect of cefozopran (SCE-2787), a new semisynthetic parenteral cephalosporin, against experimental infections in mice was examined. Cefozopran was more effective than cefpiramide and was as effective as ceftazidime and cefpirome against acute respiratory tract infections caused by Klebsiella pneumoniae DT-S. In the model of chronic respiratory tract infection caused by K. pneumoniae 27, cefozopran was as effective as ceftazidime. The therapeutic effect of cefozopran against urinary tract infections caused by Pseudomonas aeruginosa P9 was superior to that of cefpirome and was equal to those of ceftazidime and cefclidin. In addition, cefozopran was more effective than ceftazidime and was as effective as flomoxef in a thigh muscle infection caused by methicillin-sensitive Staphylococcus aureus 308A-1. Against thigh muscle infections caused by methicillin-resistant S. aureus N133, cefozopran was the most effective agent. The potent therapeutic effect of cefozopran in those experimental infections in mice suggests that it would be effective against respiratory tract, urinary tract, and soft tissue infections caused by a variety of gram-positive and gram-negative bacteria in humans.
对一种新型半合成肠道外头孢菌素头孢唑兰（SCE - 2787）在小鼠实验性感染中的治疗效果进行了研究。头孢唑兰对肺炎克雷伯菌DT - S引起的急性呼吸道感染比头孢匹胺更有效，且与头孢他啶和头孢匹罗效果相当。在肺炎克雷伯菌27引起的慢性呼吸道感染模型中，头孢唑兰与头孢他啶效果相当。头孢唑兰对铜绿假单胞菌P9引起的尿路感染的治疗效果优于头孢匹罗，与头孢他啶和头孢利定相当。此外，在甲氧西林敏感金黄色葡萄球菌308A - 1引起的大腿肌肉感染中，头孢唑兰比头孢他啶更有效，与氟氧头孢效果相当。在耐甲氧西林金黄色葡萄球菌N133引起的大腿肌肉感染中，头孢唑兰是最有效的药物。头孢唑兰在小鼠的那些实验性感染中的强效治疗效果表明，它对人类由多种革兰氏阳性和革兰氏阴性细菌引起的呼吸道、泌尿道和软组织感染可能有效。
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