Goessens W H, Fontijne P, Michel M F
Antimicrob Agents Chemother. 1984 Dec;26(6):829-32. doi: 10.1128/AAC.26.6.829.
Staphylococcus aureus strains can be divided into tolerant and nontolerant strains on the basis of their survival in vitro in the presence of high concentrations of methicillin (greater than or equal to 64 micrograms/ml). A strain is defined as tolerant if more than 2% of the inoculum survives under these conditions. The response of five susceptible and five tolerant S. aureus strains to treatment with methicillin was studied in an experimental thigh infection in mice. Animals were treated with one and two injections of methicillin (2.5 mg per mouse). At the end of treatment, the number of CFUs in the thigh muscles infected with the susceptible strains was found to be significantly lower than that in the thigh muscles infected with the tolerant
金黄色葡萄球菌菌株可根据其在高浓度甲氧西林（大于或等于64微克/毫升）存在下的体外存活情况分为耐受菌株和非耐受菌株。如果在这些条件下接种物中有超过2%存活，则该菌株被定义为耐受菌株。在小鼠大腿实验性感染中研究了五株敏感和五株耐受的金黄色葡萄球菌菌株对甲氧西林治疗的反应。动物接受一次和两次甲氧西林注射（每只小鼠2.5毫克）。治疗结束时，发现感染敏感菌株的大腿肌肉中的菌落形成单位数量明显低于感染耐受菌株的大腿肌肉中的菌落形成单位数量。
