在小鼠实验性感染中，耐甲氧西林和不耐甲氧西林金黄色葡萄球菌菌株对甲氧西林治疗的反应。
Responses of tolerant and nontolerant Staphylococcus aureus strains to methicillin treatment in an experimental infection in mice.
作者信息
Goessens W H, Fontijne P, Michel M F
出版信息
Antimicrob Agents Chemother. 1984 Dec;26(6):829-32. doi: 10.1128/AAC.26.6.829.
Abstract
Staphylococcus aureus strains can be divided into tolerant and nontolerant strains on the basis of their survival in vitro in the presence of high concentrations of methicillin (greater than or equal to 64 micrograms/ml). A strain is defined as tolerant if more than 2% of the inoculum survives under these conditions. The response of five susceptible and five tolerant S. aureus strains to treatment with methicillin was studied in an experimental thigh infection in mice. Animals were treated with one and two injections of methicillin (2.5 mg per mouse). At the end of treatment, the number of CFUs in the thigh muscles infected with the susceptible strains was found to be significantly lower than that in the thigh muscles infected with the tolerant
摘要
金黄色葡萄球菌菌株可根据其在高浓度甲氧西林（大于或等于64微克/毫升）存在下的体外存活情况分为耐受菌株和非耐受菌株。如果在这些条件下接种物中有超过2%存活，则该菌株被定义为耐受菌株。在小鼠大腿实验性感染中研究了五株敏感和五株耐受的金黄色葡萄球菌菌株对甲氧西林治疗的反应。动物接受一次和两次甲氧西林注射（每只小鼠2.5毫克）。治疗结束时，发现感染敏感菌株的大腿肌肉中的菌落形成单位数量明显低于感染耐受菌株的大腿肌肉中的菌落形成单位数量。
相似文献
1
Responses of tolerant and nontolerant Staphylococcus aureus strains to methicillin treatment in an experimental infection in mice.在小鼠实验性感染中，耐甲氧西林和不耐甲氧西林金黄色葡萄球菌菌株对甲氧西林治疗的反应。
Antimicrob Agents Chemother. 1984 Dec;26(6):829-32. doi: 10.1128/AAC.26.6.829.
2
Cell-bound and extracellular autolytic activity of a tolerant and a nontolerant Staphylococcus aureus strain exposed to methicillin.耐甲氧西林金黄色葡萄球菌菌株和非耐甲氧西林金黄色葡萄球菌菌株在接触甲氧西林后的细胞结合及细胞外自溶活性
J Antimicrob Chemother. 1986 Oct;18(4):459-66. doi: 10.1093/jac/18.4.459.
3
The role of antibiotic tolerance in the response to treatment of pyelonephritis due to Staphylococcus aureus in rats.抗生素耐受性在大鼠金黄色葡萄球菌所致肾盂肾炎治疗反应中的作用。
J Infect Dis. 1982 Feb;145(2):169-73. doi: 10.1093/infdis/145.2.169.
4
Tolerance percentage as a criterion for the detection of tolerant Staphylococcus aureus strains.作为检测耐甲氧西林金黄色葡萄球菌菌株标准的耐受百分比
Antimicrob Agents Chemother. 1984 May;25(5):575-8. doi: 10.1128/AAC.25.5.575.
5
6
In vitro activity of fosfomycin, alone and in combination, against methicillin-resistant Staphylococcus aureus.磷霉素单独及联合使用时对耐甲氧西林金黄色葡萄球菌的体外活性。
Antimicrob Agents Chemother. 1985 Nov;28(5):689-90. doi: 10.1128/AAC.28.5.689.
7
New mechanism for methicillin resistance in Staphylococcus aureus: clinical isolates that lack the PBP 2a gene and contain normal penicillin-binding proteins with modified penicillin-binding capacity.金黄色葡萄球菌对甲氧西林耐药的新机制：缺乏PBP 2a基因且含有具有修饰青霉素结合能力的正常青霉素结合蛋白的临床分离株。
Antimicrob Agents Chemother. 1989 Nov;33(11):1869-74. doi: 10.1128/AAC.33.11.1869.
8
Role of tolerance in cloxacillin treatment of experimental Staphylococcus aureus endocarditis.
J Infect Dis. 1991 Mar;163(3):640-3. doi: 10.1093/infdis/163.3.640.
9
Comparative in vitro inhibitory and killing activity of cefpirome, ceftazidime, and cefotaxime against Pseudomonas aeruginosa, enterococci, Staphylococcus epidermidis, and methicillin-susceptible and -resistant and tolerant and nontolerant Staphylococcus aureus.头孢匹罗、头孢他啶和头孢噻肟对铜绿假单胞菌、肠球菌、表皮葡萄球菌以及甲氧西林敏感和耐药、耐受和非耐受金黄色葡萄球菌的体外抑制和杀菌活性比较
Antimicrob Agents Chemother. 1985 Jul;28(1):160-2. doi: 10.1128/AAC.28.1.160.
10
Methicillin-oxacillin resistant strains of Staphylococcus aureus (MORSA) in infected burn wounds.感染烧伤创面中的耐甲氧西林 - 苯唑西林金黄色葡萄球菌（MORSA）菌株
Mater Med Pol. 1991 Oct-Dec;23(4):304-5.
引用本文的文献
1
Antibiotic tolerance among clinical isolates: mechanisms, detection, prevalence, and significance.临床分离株中的抗生素耐受性：机制、检测、流行情况及意义。
Clin Microbiol Rev. 2024 Dec 10;37(4):e0010624. doi: 10.1128/cmr.00106-24. Epub 2024 Oct 4.
2
Understanding tolerance to cell wall-active antibiotics.理解细胞壁活性抗生素的耐受性。
Ann N Y Acad Sci. 2021 Jul;1496(1):35-58. doi: 10.1111/nyas.14541. Epub 2020 Dec 3.
3
In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.针对mecA基因阳性但对苯唑西林敏感的金黄色葡萄球菌的苯唑西林疗效的体外和体内评估。
Antimicrob Agents Chemother. 2008 Nov;52(11):3905-8. doi: 10.1128/AAC.00653-08. Epub 2008 Aug 11.
4
Penicillin tolerance and treatment failure in group A streptococcal pharyngotonsillitis.A组链球菌性咽扁桃体炎中的青霉素耐受性与治疗失败
Eur J Clin Microbiol Infect Dis. 1996 Feb;15(2):107-15. doi: 10.1007/BF01591482.
5
Therapeutic effect of cefozopran (SCE-2787), a new parenteral cephalosporin, against experimental infections in mice.新型胃肠外头孢菌素头孢唑兰（SCE - 2787）对小鼠实验性感染的治疗效果
Antimicrob Agents Chemother. 1993 Jan;37(1):100-5. doi: 10.1128/AAC.37.1.100.
6
Role of tolerance in treatment and prophylaxis of experimental Staphylococcus aureus endocarditis with vancomycin, teicoplanin, and daptomycin.耐受性在万古霉素、替考拉宁和达托霉素治疗及预防实验性金黄色葡萄球菌心内膜炎中的作用
Antimicrob Agents Chemother. 1994 Mar;38(3):487-93. doi: 10.1128/AAC.38.3.487.
7
In vitro development and stability of tolerance to cloxacillin and vancomycin in Staphylococcus aureus.金黄色葡萄球菌对氯唑西林和万古霉素耐受性的体外发育及稳定性
Eur J Clin Microbiol Infect Dis. 1994 Sep;13(9):741-6. doi: 10.1007/BF02276057.
8
Efficacy of penicillin G, flucloxacillin, cefazolin, fusidic acid, vancomycin, rifampicin and fosfomycin in muscular infections in mice due to Staphylococcus aureus.青霉素G、氟氯西林、头孢唑林、夫西地酸、万古霉素、利福平和磷霉素对小鼠金黄色葡萄球菌肌肉感染的疗效。
Infection. 1986 Jan-Feb;14(1):38-43. doi: 10.1007/BF01644810.
9
Evaluation of oxacillin tolerance in Staphylococcus aureus by a novel method.用一种新方法评估金黄色葡萄球菌对苯唑西林的耐受性。
Antimicrob Agents Chemother. 1985 Sep;28(3):381-8. doi: 10.1128/AAC.28.3.381.
10
Problems in in vitro determination of antibiotic tolerance in clinical isolates.临床分离株抗生素耐受性体外测定中的问题。
Antimicrob Agents Chemother. 1986 Nov;30(5):633-7. doi: 10.1128/AAC.30.5.633.
本文引用的文献
1
Virulence to mice of Staphylococcus pyogenes: its measurement and its relation to certain in vitro properties.化脓性链球菌对小鼠的毒力：其测定及其与某些体外特性的关系。
Br J Exp Pathol. 1952 Aug;33(4):315-26.
2
The role of antibiotic tolerance in the response to treatment of pyelonephritis due to Staphylococcus aureus in rats.抗生素耐受性在大鼠金黄色葡萄球菌所致肾盂肾炎治疗反应中的作用。
J Infect Dis. 1982 Feb;145(2):169-73. doi: 10.1093/infdis/145.2.169.
3
Clinical significance of tolerant strains of Staphylococcus aureus in patients with endocarditis.金黄色葡萄球菌耐受菌株在感染性心内膜炎患者中的临床意义
Ann Intern Med. 1980 Dec;93(6):796-801. doi: 10.7326/0003-4819-93-6-796.
4
Oxacillin-tolerant staphylococcal bacteremia in children.
J Pediatr. 1980 Jun;96(6):1035-7. doi: 10.1016/s0022-3476(80)80633-0.
5
Tolerance percentage as a criterion for the detection of tolerant Staphylococcus aureus strains.作为检测耐甲氧西林金黄色葡萄球菌菌株标准的耐受百分比
Antimicrob Agents Chemother. 1984 May;25(5):575-8. doi: 10.1128/AAC.25.5.575.
6
Simplified, accurate method for antibiotic assay of clinical specimens.临床标本抗生素检测的简化、准确方法。
Appl Microbiol. 1966 Mar;14(2):170-7. doi: 10.1128/am.14.2.170-177.1966.
7
Serious staphylococcal infections with strains tolerant to bactericidal antibiotics.
Arch Intern Med. 1979 Sep;139(9):1026-31.
8
Significance of methicillin tolerance in experimental staphylococcal endocarditis.耐甲氧西林在实验性葡萄球菌性心内膜炎中的意义。
Antimicrob Agents Chemother. 1979 Jun;15(6):802-6. doi: 10.1128/AAC.15.6.802.
9
A new type of penicillin resistance of Staphylococcus aureus.
Lancet. 1977 Feb 26;1(8009):443-7. doi: 10.1016/s0140-6736(77)91941-9.
Zotero 插件