栗精胺与3'-叠氮-3'-脱氧胸苷对1型和2型人类免疫缺陷病毒体外复制的协同抑制作用
Synergistic inhibition of human immunodeficiency virus type 1 and type 2 replication in vitro by castanospermine and 3'-azido-3'-deoxythymidine.
作者信息
Johnson V A, Walker B D, Barlow M A, Paradis T J, Chou T C, Hirsch M S
机构信息
Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114.
出版信息
Antimicrob Agents Chemother. 1989 Jan;33(1):53-7. doi: 10.1128/AAC.33.1.53.
Abstract
Castanospermine and 3'-azido-3'-deoxythymidine (zidovudine) were evaluated in combination against human immunodeficiency virus (HIV) replication in vitro. Castanospermine and 3'-azido-3'-deoxythymidine inhibited HIV type 1 synergistically in acutely infected H9 cells. In addition, they synergistically inhibited both HIV type 1 and HIV type 2 in peripheral blood mononuclear cells. There were no additional toxic effects of these agents in combination. Drug interactions were evaluated by the median-effect principle and the isobologram technique. Combinations of a glycosylation inhibitor, such as castanospermine, with 3'-azido-3'-deoxythymidine deserve consideration for HIV-related chemotherapeutic intervention.
摘要
对栗精胺和3'-叠氮-3'-脱氧胸苷（齐多夫定）联合抗人免疫缺陷病毒（HIV）体外复制的效果进行了评估。栗精胺和3'-叠氮-3'-脱氧胸苷在急性感染的H9细胞中对1型HIV具有协同抑制作用。此外，它们在外周血单核细胞中对1型HIV和2型HIV均有协同抑制作用。这些药物联合使用没有额外的毒性作用。通过中位效应原理和等效线图技术评估药物相互作用。糖基化抑制剂如栗精胺与3'-叠氮-3'-脱氧胸苷的联合用药值得考虑用于HIV相关的化疗干预。
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