McKee B D, Handel M A
Department of Zoology, University of Tennessee, Knoxville 37996.
Chromosoma. 1993 Jan;102(2):71-80. doi: 10.1007/BF00356023.
We review what is known about the transcriptional inactivation and condensation of heteromorphic sex chromosomes in contrast to the activation of homomorphic sex chromosomes during meiotic prephase in animals. We relate these cytological and transcriptional features to the recombination status of the sex chromosomes. We propose that sex chromosome condensation is a meiotic adaptation to prevent the initiation of potentially damaging recombination events in nonhomologous regions of the X and Y chromosome.
我们回顾了与动物减数分裂前期同型性染色体激活相反的异型性染色体转录失活和浓缩的相关知识。我们将这些细胞学和转录特征与性染色体的重组状态联系起来。我们提出，性染色体浓缩是一种减数分裂适应性变化，以防止在X和Y染色体的非同源区域启动潜在的有害重组事件。
