Grajek S, Lesiak M, Pyda M, Zajac M, Paradowski S, Kaczmarek E
1st Department of Cardiology, Medical Academy, Poznań, Poland.
Eur Heart J. 1993 Jan;14(1):40-7. doi: 10.1093/eurheartj/14.1.40.
In 103 hearts with various forms of cardiac muscle hypertrophy the following parameters were estimated: diameter, length, volume, density and number of myocytes, and density of myocyte nuclei. The values of all histometric parameters correlated well with left ventricular (LV) weight up to 350 g. In heavier hearts these parameters remained approximately of the same magnitude. The number of myocytes was significantly higher in hearts with LV weight above 250 g. The influence on LV weight of age, coronary artery diameters, degree of atherosclerosis, weight and percent of fibrous tissue was also evaluated. On the basis of a linear discriminant function, hearts were divided into three classes: (1) LV weight < or = 250 g (absence of hyperplasia, hypertrophy only); (2) LV weight 251-350 g (hypertrophy+signs of hyperplasia); (3) LV weight > 350 g (marked signs of hyperplasia). The percent of fibrosis increased proportionally to LV weight. Where LV weight was above 250 g there was a subsequent increase in the mean percent of fibrosis (approx. 26%). This phenomenon (plateau of percent fibrosis) is the result of an increased number of myocytes (myocyte hyperplasia). We suggest that, independent of aetiology, in all hearts above 350 g (patients with congestive heart failure) hyperplasia phenomenon exists.
在103例患有各种形式心肌肥厚的心脏中，评估了以下参数：心肌细胞的直径、长度、体积、密度和数量，以及心肌细胞核的密度。所有组织测量参数的值与左心室（LV）重量在350克以内时相关性良好。在更重的心脏中，这些参数大致保持相同水平。左心室重量超过250克的心脏中，心肌细胞数量显著更高。还评估了年龄、冠状动脉直径、动脉粥样硬化程度、纤维组织重量和百分比对左心室重量的影响。基于线性判别函数，心脏被分为三类：（1）左心室重量≤250克（无增生，仅肥大）；（2）左心室重量251 - 350克（肥大+增生迹象）；（3）左心室重量>350克（明显的增生迹象）。纤维化百分比与左心室重量成比例增加。当左心室重量超过250克时，纤维化的平均百分比随后增加（约26%）。这种现象（纤维化百分比平台期）是心肌细胞数量增加（心肌细胞增生）的结果。我们认为，无论病因如何，在所有左心室重量超过350克的心脏（充血性心力衰竭患者）中都存在增生现象。
