Gaeta G B, Maisto A, Sichenze C, Satriano R A, Sardaro C, Giusti G
Clinica Malattie Infettive, Seconda Universita, Naples, Italy.
Infection. 1994 Mar-Apr;22(2):77-80. doi: 10.1007/BF01739008.
A case-control study was performed to evaluate the prevalence of mucocutaneous diseases in 106 male drug addicts (age 21-38 years) with or without HIV infection. A mucocutaneous disease was recorded in ten out of 64 HIV-negative and in 20 of 42 HIV-positive patients (OR = 4.9; p < 0.01). Some mucocutaneous diseases were present in similar proportions in both groups (i.e. fungal skin lesions), while others were typically present only in HIV-positive patients. Stratification for possible confounding factors, such as years of drug addiction and number of sexual partners, confirmed that HIV infection is the main risk factor for mucocutaneous disease. Stratification according to the number of CD4-positive cells showed that the more advanced the HIV disease, the more frequently mucocutaneous disease was present (p = 0.02). The study demonstrates that many, but not all, mucocutaneous diseases are associated with HIV infection.
开展了一项病例对照研究，以评估106名年龄在21至38岁之间、感染或未感染HIV的男性吸毒者中皮肤黏膜疾病的患病率。在64名HIV阴性患者中有10名记录有皮肤黏膜疾病，42名HIV阳性患者中有20名记录有皮肤黏膜疾病（比值比=4.9；p<0.01）。两组中某些皮肤黏膜疾病的比例相似（如皮肤真菌病变），而其他一些疾病则仅在HIV阳性患者中典型出现。对可能的混杂因素进行分层，如吸毒年限和性伴侣数量，证实HIV感染是皮肤黏膜疾病的主要危险因素。根据CD4阳性细胞数量进行分层显示，HIV疾病越严重，皮肤黏膜疾病出现的频率越高（p=0.02）。该研究表明，许多但并非所有的皮肤黏膜疾病都与HIV感染有关。
