Tosi P, Filipe M I, Luzi P, Miracco C, Santopietro R, Lio R, Sforza V, Barbini P
Institute of Pathological Anatomy and Histopathology, University of Siena, Italy.
J Pathol. 1993 Jan;169(1):73-8. doi: 10.1002/path.1711690112.
The aim of this study was to try to place gastric intestinal metaplasia, type III (type III IM) in the stepwise chain of events from atrophic gastritis to cancer. A number of dysplastic, periulcer regenerative, and type III IM lesions were qualitatively diagnosed (and graded) blindly and independently by several pathologists. These lesions were further analysed by means of quantitative parameters, with the aim of differentiating dysplastic from regenerative changes. Inconsistencies between the qualitative and quantitative classification (about 7 per cent of cases) were eliminated and homogeneous groups (low-grade dysplasia, high-grade dysplasia, regenerative changes) were obtained. These cases were taken as the gold standard against which type III IM was compared. The results indicate that the great majority (91.4 per cent) of cases of type III IM fulfil the nuclear and architectural criteria for low-grade dysplasia.
本研究的目的是尝试将Ⅲ型胃黏膜肠化生（Ⅲ型IM）置于从萎缩性胃炎到癌症的一系列连续事件中。若干发育异常、溃疡周围再生和Ⅲ型IM病变由几位病理学家进行了盲法独立定性诊断（和分级）。通过定量参数对这些病变进行进一步分析，目的是区分发育异常与再生性改变。消除了定性和定量分类之间的不一致（约7%的病例），获得了同质组（低级别发育异常、高级别发育异常、再生性改变）。将这些病例作为与Ⅲ型IM进行比较的金标准。结果表明，绝大多数（91.4%）的Ⅲ型IM病例符合低级别发育异常的核和结构标准。
