小脑切除对动机相关行为的影响：一项时间进程研究。

Effects of cerebellectomy on motivation-related behavior: a time-course study.

作者信息

D'Agata V, Drago F, Serapide F, Cicirata F

机构信息

Institute of Pharmacology, University of Catania Medical School, Italy.

出版信息

Physiol Behav. 1993 Jan;53(1):173-6. doi: 10.1016/0031-9384(93)90027-d.

DOI:10.1016/0031-9384(93)90027-d

PMID:8434059

Abstract

The open field behavior and learning capacity of male rats of the Wistar strain was studied 1, 2, and 6 months after cerebellectomy (CBX). The results show a decrease in locomotor activity 1 month after CBX and thereafter a slow recovery. Grooming behavior was still normal after 1 month, but it decreased 2 months after CBX. Learning capacity, as assessed by the shuttle-box test, was remarkably decreased in cerebellectomized animals 1 month after operation. A significant impairment of memory capacity was also observed in rats tested for passive avoidance behavior 2 months after CBX. A partial recovery of this parameter was present 6 months after operation. These results support the hypothesis of a possible influence of cerebellum on motivation-related behaviors, independently of its modulatory role on motricity.

摘要

对Wistar品系雄性大鼠在小脑切除术后1个月、2个月和6个月的旷场行为和学习能力进行了研究。结果显示，小脑切除术后1个月运动活动减少，此后缓慢恢复。梳理行为在术后1个月仍正常，但在小脑切除术后2个月减少。通过穿梭箱试验评估，小脑切除术后1个月的动物学习能力显著下降。在小脑切除术后2个月进行被动回避行为测试的大鼠中也观察到记忆能力的显著损害。术后6个月该参数部分恢复。这些结果支持小脑可能对动机相关行为有影响的假说，这与其对运动性的调节作用无关。