Dahhaoui M, Caston J, Auvray N, Reber A
Laboratoire de Neurophysiologie sensorielle, Faculté des Sciences de Rouen, Mont-Saint-Aignan, France.
Physiol Behav. 1990 Jun;47(6):1175-80. doi: 10.1016/0031-9384(90)90369-f.
Adult DA/HAN strain male rats were submitted to an avoidance conditioning procedure. They were divided into two experimental groups, the animals being either conditioned (COC group) or not (NOC group) before cerebellectomy, and two control groups, the animals being either intact (C group) or sham-operated (SO group). Although the NOC rats could be conditioned successfully and the cerebellum is not absolutely necessary for the avoidance conditioning achievement, their scores were significantly lower than the preoperative scores of COC rats. Moreover, the scores of NOC rats (postoperative scores) were significantly lower than the postoperative scores of COC animals, suggesting that the preoperative conditioning makes the postoperative conditioning easier. At last, comparing postoperative scores of COC rats with those obtained by C and SO rats when given the retrieval test and comparing preoperative and postoperative scores in COC animals show that retention of the initial (preoperative) conditioning is partly abolished by the cerebellectomy. Histological controls demonstrated that the entire cerebellum except for the flocculus and the nodulus was removed. These results strongly suggest that the cerebellum is involved in the memory processes that sustain the avoidance conditioning.
成年DA/HAN品系雄性大鼠接受了回避条件反射程序。它们被分为两个实验组，一组在小脑切除术前进行了条件反射训练（COC组），另一组未进行（NOC组），还有两个对照组，一组为完整大鼠（C组），另一组为假手术大鼠（SO组）。尽管NOC大鼠能够成功建立条件反射，并且小脑对于完成回避条件反射并非绝对必要，但它们的得分显著低于COC大鼠术前的得分。此外，NOC大鼠的得分（术后得分）显著低于COC动物的术后得分，这表明术前的条件反射训练使术后的条件反射训练更容易。最后，在进行检索测试时，将COC大鼠的术后得分与C组和SO组大鼠的得分进行比较，并比较COC动物术前和术后的得分，结果表明小脑切除部分消除了最初（术前）条件反射的记忆。组织学检查证实，除绒球和小结外，整个小脑均被切除。这些结果有力地表明，小脑参与了维持回避条件反射的记忆过程。
