Gabrilovich D I, Avdeeva L A, Serebrovskaya L V, Shepeleva G K, Suvorova Z K, Buravcova E V, Oganezov V K, Platonov A E, Habarova V V, Posly I M
Laboratory of AIDS Epidemiology and Prevention, Central Institute for Epidemiology, Moscow, Russia.
Scand J Immunol. 1993 Feb;37(2):159-64. doi: 10.1111/j.1365-3083.1993.tb01752.x.
The impact of the sera from 64 HIV-1-infected patients on the functional activity of polymorphonuclear neutrophils (PMN) from 9 healthy donors was investigated. Augmentation of PMN oxygen radical production in the presence of sera from HIV-infected patients (PMN chemiluminescence) was demonstrated. This enhancement was connected with intracellular generation of chemiluminescence (CL). A significant correlation between this enhancement and stages of HIV infection was not found. The presence of the sera from HIV-infected patients in the incubation media led to a decrease of PMN phagocytosis. It was found that contrary impact of the sera on PMN CL and phagocytosis was connected with different factors. The decrease of PMN phagocytosis correlated with the level of complement and was independent of other factors. At the same time the increase of PMN CL was not connected with the level of complement activity but correlated with the level of anti-HIV antibody and circulating immune complexes. The reasons for this phenomenon are unclear. It was suggested that one of the serum factors which caused increase of PMN CL is HIV or HIV compounds.
研究了64例HIV-1感染患者的血清对9名健康供体多形核中性粒细胞（PMN）功能活性的影响。结果表明，在HIV感染患者血清存在的情况下，PMN氧自由基生成增加（PMN化学发光）。这种增强与细胞内化学发光（CL）的产生有关。未发现这种增强与HIV感染阶段之间存在显著相关性。在孵育培养基中加入HIV感染患者的血清会导致PMN吞噬作用降低。发现血清对PMN CL和吞噬作用的相反影响与不同因素有关。PMN吞噬作用的降低与补体水平相关，且与其他因素无关。同时，PMN CL的增加与补体活性水平无关，但与抗HIV抗体和循环免疫复合物水平相关。这种现象的原因尚不清楚。有人提出，导致PMN CL增加的血清因子之一是HIV或HIV化合物。
