Gabrilovich D I, Ivanova L A, Shepeleva G K, Serebrovskaia L V, Buravtsova E V, Pokrovskiĭ V V
Zh Mikrobiol Epidemiol Immunobiol. 1995 Sep-Oct(5):56-60.
The influence of 64 blood serum samples from HIV-infected patients at different stages of the infection on the functional activity of polymorphonuclear neutrophils (PMN) of 9 healthy donors was studied. In this study an increase in the production of oxygen radicals by PMN of the donors was revealed (in the chemiluminescence test), positive correlations between this increase and stages of HIV infection were followed. The presence of HIV-positive serum in the incubation medium led to the inhibition of phagocytosis and produced almost no changes in the capacity of PMN for its completion. A decrease in phagocytosis correlated with the level of complement and did not depend on other serum factors; on the contrary, an increase in chemiluminescence was not linked with the levels of complement, but had correlative relationships with the levels of anti-HIV antibodies and circulating immune complexes.
研究了64份来自处于不同感染阶段的HIV感染患者的血清样本对9名健康供体多形核中性粒细胞（PMN）功能活性的影响。在本研究中，发现供体的PMN产生氧自由基增加（化学发光试验），且这种增加与HIV感染阶段呈正相关。孵育培养基中HIV阳性血清的存在导致吞噬作用受到抑制，且PMN完成吞噬作用的能力几乎没有变化。吞噬作用的降低与补体水平相关，且不依赖于其他血清因子；相反，化学发光的增加与补体水平无关，但与抗HIV抗体水平和循环免疫复合物水平存在相关关系。
