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相似文献

1
A pharmacokinetic model to study the excretion of trichloroethylene and its metabolites after an inhalation exposure.一个用于研究吸入暴露后三氯乙烯及其代谢物排泄情况的药代动力学模型。
Br J Ind Med. 1977 Feb;34(1):56-63. doi: 10.1136/oem.34.1.56.
2
Trichloroethylene exposure. Simulation of uptake, excretion, and metabolism using a mathematical model.三氯乙烯暴露。使用数学模型模拟吸收、排泄和代谢。
Br J Ind Med. 1977 Feb;34(1):43-55. doi: 10.1136/oem.34.1.43.
3
Differences following skin or inhalation exposure in the absorption and excretion kinetics of trichloroethylene and toluene.经皮肤或吸入接触后，三氯乙烯和甲苯在吸收及排泄动力学方面的差异。
Br J Ind Med. 1978 Feb;35(1):43-9. doi: 10.1136/oem.35.1.43.
4
A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol.一种基于人体生理学的三氯乙烯及其代谢产物三氯乙酸和游离三氯乙醇的药代动力学模型。
Toxicol Appl Pharmacol. 1998 Oct;152(2):339-59. doi: 10.1006/taap.1998.8486.
5
[Accumulation kinetics of trichloroethylene and its metabolites during multiple exposures. A theoretical study (author's transl)].
Sangyo Igaku. 1979 Jul;21(4):361-5. doi: 10.1539/joh1959.21.361.
6
Physiologically based pharmacokinetic modeling of inhaled trichloroethylene and its oxidative metabolites in B6C3F1 mice.B6C3F1小鼠吸入三氯乙烯及其氧化代谢产物的生理药代动力学建模
Toxicol Appl Pharmacol. 1999 Feb 1;154(3):264-78. doi: 10.1006/taap.1998.8594.
7
[Estimation of rate constants for absorption, metabolism and excretion of trichloroethylene from urinary excretion data (author's transl)].
Sangyo Igaku. 1977 Mar;19(2):92-3.
8
[Excretion of trichloroethanol and trichloracetic acid in the urine of rats exposed repeatedly to trichlorethylene (author's transl)].
Sangyo Igaku. 1977 Sep;19(5):251-5.
9
[Individual differences in the kinetic behavior of trichloroethylene. A simulation study using a physiological pharmacokinetic model].[三氯乙烯动力学行为的个体差异。使用生理药代动力学模型的模拟研究]
Sangyo Igaku. 1989 Sep;31(5):348-54. doi: 10.1539/joh1959.31.348.
10
Dose-based duration adjustments for the effects of inhaled trichloroethylene on rat visual function.基于剂量的吸入三氯乙烯对大鼠视觉功能影响的持续时间调整
Toxicol Sci. 2003 Nov;76(1):121-30. doi: 10.1093/toxsci/kfg213. Epub 2003 Aug 12.

引用本文的文献

1
Statistical analysis of Clewell et al. PBPK model of trichloroethylene kinetics.克莱韦尔等人三氯乙烯动力学的生理药代动力学（PBPK）模型的统计分析。
Environ Health Perspect. 2000 May;108 Suppl 2(Suppl 2):307-16. doi: 10.1289/ehp.00108s2307.
2
Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment.开发一种基于生理学的三氯乙烯及其代谢物药代动力学模型，用于风险评估。
Environ Health Perspect. 2000 May;108 Suppl 2(Suppl 2):283-305. doi: 10.1289/ehp.00108s2283.
3
Physiologically based pharmacokinetic models for trichloroethylene and its oxidative metabolites.基于生理学的三氯乙烯及其氧化代谢物的药代动力学模型。
Environ Health Perspect. 2000 May;108 Suppl 2(Suppl 2):265-73. doi: 10.1289/ehp.00108s2265.
4
Metabolism of trichloroethylene.三氯乙烯的代谢
Environ Health Perspect. 2000 May;108 Suppl 2(Suppl 2):177-200. doi: 10.1289/ehp.00108s2177.
5
Effect of various exposure scenarios on the biological monitoring of organic solvents in alveolar air. II. 1,1,1-Trichloroethane and trichloroethylene.不同暴露场景对肺泡气中有机溶剂生物监测的影响。II. 1,1,1-三氯乙烷和三氯乙烯。
Int Arch Occup Environ Health. 1995;67(6):375-94. doi: 10.1007/BF00381051.
6
Acute effects of trichloroethylene on blood concentrations and performance decrements in rats and their relevance to humans.三氯乙烯对大鼠血液浓度及行为能力下降的急性影响及其与人类的相关性。
Br J Ind Med. 1993 May;50(5):470-80. doi: 10.1136/oem.50.5.470.
7
Physiologicomathematical model for studying human exposure to organic solvents: kinetics of blood/tissue n-hexane concentrations and of 2,5-hexanedione in urine.用于研究人体接触有机溶剂的生理数学模型：血液/组织中正己烷浓度及尿中2,5 -己二酮的动力学
Br J Ind Med. 1986 Nov;43(11):760-8. doi: 10.1136/oem.43.11.760.
8
Intra and interindividual variability in the kinetics of a poorly and highly metabolising solvent.一种低代谢和高代谢溶剂动力学的个体内和个体间变异性。
Br J Ind Med. 1989 Dec;46(12):831-45. doi: 10.1136/oem.46.12.831.
9
A simulation study of physiological factors affecting pharmacokinetic behaviour of organic solvent vapours.影响有机溶剂蒸气药代动力学行为的生理因素的模拟研究。
Br J Ind Med. 1991 May;48(5):342-7. doi: 10.1136/oem.48.5.342.
10
Effects of ethanol and phenobarbital treatments on the pharmacokinetics of toluene in rats.乙醇和苯巴比妥处理对大鼠甲苯药代动力学的影响。
Br J Ind Med. 1992 Feb;49(2):104-12. doi: 10.1136/oem.49.2.104.

本文引用的文献

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The theory and applications of the exchange of inert gas at the lungs and tissues.惰性气体在肺部和组织中的交换理论与应用。
Pharmacol Rev. 1951 Mar;3(1):1-41.
2
Evaluating trichloroethylene exposures by urinalyses for trichloroacetic acid.
AMA Arch Ind Hyg Occup Med. 1951 Apr;3(4):386-98.
3
THE METABOLISM OF 36C1-LABELLED TRICHLOROETHYLENE AND TETRACHLOROETHYLENE IN THE RAT.大鼠体内36C1标记的三氯乙烯和四氯乙烯的代谢
Biochem Pharmacol. 1963 Aug;12:795-802. doi: 10.1016/0006-2952(63)90109-6.
4
Observations on the concentrations of trichloroethylene in blood and expired air following exposure of humans.人体暴露于三氯乙烯后血液和呼出气体中三氯乙烯浓度的观察结果。
Am Ind Hyg Assoc J. 1962 Mar-Apr;23:167-70. doi: 10.1080/00028896209343221.
5
Metabolism and excretion of trichloroethylene after inhalation by human subjects.人体吸入三氯乙烯后的代谢与排泄
Br J Ind Med. 1962 Apr;19(2):134-41. doi: 10.1136/oem.19.2.134.
6
Excretory and biologic threshold limits.排泄及生物阈限值。
Am Ind Hyg Assoc J. 1967 Jul-Aug;28(4):305-14. doi: 10.1080/00028896709342528.
7
Method for estimating rate constants for absorption, metabolism, and elimination from urinary excretion data.
J Pharm Sci. 1967 Apr;56(4):489-94. doi: 10.1002/jps.2600560413.
8
A more rational basis for air sampling programs.空气采样计划更合理的依据。
Am Ind Hyg Assoc J. 1966 Jan-Feb;27(1):1-12. doi: 10.1080/00028896609342786.
9
Metabolism of trichloroethylene in liver microsomes. II. Identification of the reaction product as chloral hydrate.三氯乙烯在肝微粒体中的代谢。II. 反应产物为水合氯醛的鉴定。
Mol Pharmacol. 1965 Nov;1(3):247-54.
10
Intertissue diffusion effect for inert fat-soluble gases.惰性脂溶性气体的组织间扩散效应
J Appl Physiol. 1965 Jul;20(4):621-7. doi: 10.1152/jappl.1965.20.4.621.

一个用于研究吸入暴露后三氯乙烯及其代谢物排泄情况的药代动力学模型。

A pharmacokinetic model to study the excretion of trichloroethylene and its metabolites after an inhalation exposure.

作者信息

Sato A, Nakajima T, Fujiwara Y, Murayama N

出版信息

Br J Ind Med. 1977 Feb;34(1):56-63. doi: 10.1136/oem.34.1.56.

DOI:10.1136/oem.34.1.56
PMID:843464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1008172/
Abstract

For a better understanding of absorption, distribution, excretion, and metabolism of trichloroethylene the time-course of blood concentration of the vapour and urinary excretion of its metabolites was examined using a pharmacokinetic model. After a single experimental exposure in which four men inhaled 100 parts per million (ppm) of trichloroethylene for four hours an elimination curve showed three exponential components, that is, X=1-0005e(-16.71t)+0-449e(-1.710t)+0-255e(-0.2027t), where X is that blood concentration in mg/l and t the time in hours from 0 to 10. The overall rate constant for the disappearance of trichloroethylene was found to a agree with the theoretical one, estimated by means of a mathematical model for the blood concentration data. A D8- XD plot, developed from a mathematical model for urinary excretion, could also give a good estimate of rate constant for the transfer of trichloroethylene in the body. The rate constant thus estimated from urinary excretion was consistent with data on the blood concentration.

摘要

为了更好地理解三氯乙烯的吸收、分布、排泄和代谢情况，使用药代动力学模型研究了三氯乙烯蒸气血药浓度的时程及其代谢产物的尿排泄情况。在一次单次实验暴露中，四名男性吸入百万分之100（ppm）的三氯乙烯4小时，消除曲线显示出三个指数成分，即X = 1.0005e^(-16.71t) + 0.449e^(-1.710t) + 0.255e^(-0.2027t)，其中X是以mg/l为单位的血药浓度，t是从0到10小时的时间。发现三氯乙烯消失的总体速率常数与通过血药浓度数据的数学模型估算的理论值相符。从尿排泄的数学模型得出的D8 - XD图，也能很好地估算三氯乙烯在体内转移的速率常数。由此从尿排泄估算出的速率常数与血药浓度数据一致。