影响有机溶剂蒸气药代动力学行为的生理因素的模拟研究。
A simulation study of physiological factors affecting pharmacokinetic behaviour of organic solvent vapours.
作者信息
Sato A, Endoh K, Kaneko T, Johanson G
机构信息
Department of Environmental Health, Medical University of Yamanashi, Japan.
出版信息
Br J Ind Med. 1991 May;48(5):342-7. doi: 10.1136/oem.48.5.342.
Abstract
At a given external dose of an inhaled chemical the internal dose or the amount absorbed into the body varies depending on pulmonary ventilation and other physiological factors. Such variability is of concern in the development of biological indices of occupational exposure to organic solvent vapours. This paper discusses how physiological factors may influence the pharmacokinetic behaviour of inhaled organic solvent vapours, especially in relation to monitoring of biological exposure. To illustrate the discussion a computer based physiological pharmacokinetic model was used describing quantitatively the influence of body size, body fat content, and sex on the pharmacokinetic behaviour of trichloroethylene. Absorption, distribution, metabolism and excretion of trichloroethylene were found to vary according to the different anatomical features of men and women. Body build (body weight and body fat content) also affected the pharmacokinetic behaviour of this solvent.
摘要
在吸入化学物质的给定外部剂量下，体内剂量或吸收到体内的量会因肺通气和其他生理因素而有所不同。这种变异性在有机溶剂蒸气职业暴露生物指标的制定中备受关注。本文讨论了生理因素如何影响吸入有机溶剂蒸气的药代动力学行为，特别是与生物暴露监测相关的方面。为了说明讨论内容，使用了一个基于计算机的生理药代动力学模型，定量描述了体型、体脂含量和性别对三氯乙烯药代动力学行为的影响。发现三氯乙烯的吸收、分布、代谢和排泄因男性和女性不同的解剖特征而有所差异。体型（体重和体脂含量）也影响了这种溶剂的药代动力学行为。
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