Brasch J, Christophers E
Department of Dermatology, University of Kiel, FRG.
Dermatology. 1993;186(1):55-8. doi: 10.1159/000247303.
Azelaic acid is a therapeutic agent with well-known antibacterial properties, but its antimycotic effect has not yet been investigated systematically. In this study we have used an agar dilution technique to test the inhibitory effect of azelaic acid upon common dermatophytes, Scopulariopsis brevicaulis, Candida albicans, Candida glabrata and Pityrosporum ovale. As a result, the growth of dermatophytes and S. brevicaulis was suppressed by 0.56% azelaic acid and that of P. ovale by 1%. By 4% azelaic acid C. glabrata was inhibited completely, but C. albicans still maintained some growth. The antimycotic effect of azelaic acid occurred at pH values between 4.8 and 5.5, whereas its disodium salt had no such effect at pH 6.1. Considering the favorable pharmacological data of azelaic acid, our results give reason to investigate the antimycotic effect of this agent in vivo.
壬二酸是一种具有众所周知抗菌特性的治疗剂，但其抗真菌作用尚未得到系统研究。在本研究中，我们使用琼脂稀释技术来测试壬二酸对常见皮肤癣菌、短帚霉、白色念珠菌、光滑念珠菌和卵形糠秕孢子菌的抑制作用。结果，0.56%的壬二酸可抑制皮肤癣菌和短帚霉的生长，1%的壬二酸可抑制卵形糠秕孢子菌的生长。4%的壬二酸可完全抑制光滑念珠菌，但白色念珠菌仍有一定生长。壬二酸的抗真菌作用发生在pH值4.8至5.5之间，而其二钠盐在pH 6.1时无此作用。鉴于壬二酸良好的药理学数据，我们的结果为研究该药物在体内的抗真菌作用提供了依据。
