Williams R E, MacKie R M
Department of Dermatology, University of Glasgow, Scotland, United Kingdom.
Dermatol Clin. 1993 Jan;11(1):201-6.
For skin diseases such as impetigo and furunculosis in which infection with S. aureus is the primary pathologic event, control of that infection is obviously paramount in the management of the clinical situation. The available antistaphylococcal agents are highly effective, and topical mupirocin has been a valuable recent addition. In conditions such as AD the position is less clear. Because the presence of the underlying disease is a prerequisite for the staphylococcal colonization, the exact role of staphylococcal damage is difficult to separate from the underlying disease activity. The definitive experiment, whereby staphylococcal colonization is eradicated over a prolonged period of time by a nonirritant method, remains to be performed. Until that time it is reasonable to pursue a policy of treating S. aureus colonization when it is believed to be of clinical significance and not simply on the basis of bacteriologic findings.
对于诸如脓疱病和疖病等以金黄色葡萄球菌感染为主要病理事件的皮肤病，控制该感染显然是临床处理的首要任务。现有的抗葡萄球菌药物非常有效，局部用莫匹罗星是近期一项有价值的补充。在特应性皮炎等病症中，情况则不太明确。由于潜在疾病的存在是葡萄球菌定植的先决条件，所以很难将葡萄球菌造成的损害的确切作用与潜在疾病的活动区分开来。通过非刺激性方法长期根除葡萄球菌定植的决定性实验仍有待进行。在此之前，采取一种在认为金黄色葡萄球菌定植具有临床意义时（而不仅仅基于细菌学检查结果）进行治疗的策略是合理的。
