Császár A, Dieplinger H, Sandholzer C, Karádi I, Juhász E, Drexel H, Halmos T, Romics L, Patsch J R, Utermann G
Institute of Medical Biology and Human Genetics, University of Innsbruck, Austria.
Diabetologia. 1993 Jan;36(1):47-51. doi: 10.1007/BF00399092.
Patients with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus are at increased risk of developing atherosclerotic vascular diseases. A variety of lipoprotein abnormalities have been described as being associated with this increased risk. In this study, apo(a) isoform frequencies and lipoprotein(a) [Lp(a)] concentrations were determined in Type 1 and Type 2 diabetic patients in order to investigate a possible contribution of Lp(a) to the increased risk for atherosclerosis in diabetes. No significant differences in plasma Lp(a) concentrations were found in two ethnically different populations (Austrians from the province of Tyrol and Hungarians from Budapest) in either type of diabetes when compared to respective control groups (91 Type 1 and 112 Type 2 diabetic patients vs 202 control subjects in the Hungarian study and 44 Type 1 diabetic and 44 Type 2 diabetic vs 125 control subjects in the Austrian study). There were also no significant apo(a) isoform frequency differences between both patient groups and control subjects in the two study groups. These data, obtained from two large ethnically different populations, provide no evidence of a contribution of Lp(a) to the increased risk for atherosclerosis in diabetes.
1型（胰岛素依赖型）和2型（非胰岛素依赖型）糖尿病患者发生动脉粥样硬化性血管疾病的风险增加。多种脂蛋白异常被认为与这种风险增加有关。在本研究中，测定了1型和2型糖尿病患者的载脂蛋白(a)异构体频率和脂蛋白(a)[Lp(a)]浓度，以研究Lp(a)对糖尿病患者动脉粥样硬化风险增加的可能作用。在两个种族不同的人群（来自蒂罗尔省的奥地利人和来自布达佩斯的匈牙利人）中，无论是哪种类型的糖尿病，与各自的对照组相比，血浆Lp(a)浓度均未发现显著差异（匈牙利研究中91例1型和112例2型糖尿病患者与202例对照受试者，奥地利研究中44例1型糖尿病患者和44例2型糖尿病患者与125例对照受试者）。两个研究组的患者组和对照受试者之间的载脂蛋白(a)异构体频率也没有显著差异。这些来自两个种族不同的大样本人群的数据，没有提供Lp(a)对糖尿病患者动脉粥样硬化风险增加有作用的证据。
