噬菌体λ中中心不对称性对回文DNA传播的影响与体内十字形结构挤出一致。
The effects of central asymmetry on the propagation of palindromic DNA in bacteriophage lambda are consistent with cruciform extrusion in vivo.
作者信息
Chalker A F, Okely E A, Davison A, Leach D R
机构信息
Institute of Cell and Molecular Biology, University of Edinburgh, Scotland.
出版信息
Genetics. 1993 Feb;133(2):143-8. doi: 10.1093/genetics/133.2.143.
Abstract
The propagation of lambda phages carrying long perfect palindromes has been compared with that of phages carrying imperfect palindromes with small regions of central asymmetry. The perfect palindromes confer a more deleterious phenotype than those with central asymmetry and the severity of the phenotype declines with the length of asymmetry in the range from O to 27 base pairs. These results argue that a center-dependent reaction is involved in the phenotypic effects of palindromic DNA sequences, consistent with the idea that cruciform extrusion occurs in vivo.
摘要
携带长完美回文序列的λ噬菌体的繁殖已与携带具有中心不对称小区域的不完美回文序列的噬菌体的繁殖进行了比较。完美回文序列比具有中心不对称的回文序列赋予更有害的表型，并且表型的严重程度随着不对称长度在0至27个碱基对范围内而下降。这些结果表明，中心依赖性反应参与了回文DNA序列的表型效应，这与十字形挤出在体内发生的观点一致。
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