Terasawa A, Miyatake K, Nakatani S, Yamagishi M, Matsuda H, Beppu S
Cardiology Division of Medicine, National Cardiovascular Center, Osaka, Japan.
J Am Coll Cardiol. 1993 Mar 1;21(3):737-42. doi: 10.1016/0735-1097(93)90107-c.
The objective of this study was to evaluate the effect of a transpulmonary contrast agent on Doppler flow signals in the left heart chambers.
Echo contrast agents are good ultrasound reflectors and could be used as Doppler signal enhancers. Sonicated albumin microbubbles are transpulmonary echo contrast agents and could enhance left heart Doppler signals after peripheral venous injection.
Thirty-one patients with various heart diseases without intracardiac shunts were assessed with Doppler echocardiography before and after injection of sonicated albumin.
After an intravenous injection, pulsed Doppler signals of transmitral flow became more intense in all 16 patients examined, although flow velocity itself was not changed. In Doppler color flow imaging, the maximal mitral regurgitant signal area increased from 312 +/- 405 mm2 to 434 +/- 465 mm2, an average increase of 59 +/- 40% in all 17 patients with mitral regurgitation (p < 0.01). These effects were considered to be due to improvement of signal to noise ratio by the enhancement of Doppler flow signals. The duration of enhancement of pulsed Doppler transmitral flow signals was significantly longer than that of the left ventricular echocardiographic opacification (44 +/- 11 s vs. 17 +/- 7 s, p < 0.01).
Intravenous injection of sonicated albumin can enhance the Doppler flow signals in the left heart chambers. This effect may be useful to improve the sensitivity of the Doppler system for detecting abnormalities of left heart blood flow such as mitral regurgitation.
本研究的目的是评估经肺造影剂对左心腔多普勒血流信号的影响。
超声造影剂是良好的超声反射体，可用作多普勒信号增强剂。超声处理的白蛋白微泡是经肺超声造影剂，经外周静脉注射后可增强左心多普勒信号。
对31例无心脏内分流的各种心脏病患者在注射超声处理的白蛋白前后进行多普勒超声心动图评估。
静脉注射后，在所检查的所有16例患者中，二尖瓣血流的脉冲多普勒信号变得更强，尽管流速本身未改变。在多普勒彩色血流成像中，所有17例二尖瓣反流患者的最大二尖瓣反流信号面积从312±405mm²增加到434±465mm²，平均增加59±40%（p<0.01）。这些效应被认为是由于多普勒血流信号增强提高了信噪比所致。脉冲多普勒二尖瓣血流信号增强的持续时间明显长于左心室超声造影的持续时间（44±11秒对17±7秒，p<0.01）。
静脉注射超声处理的白蛋白可增强左心腔的多普勒血流信号。这种效应可能有助于提高多普勒系统检测左心血流异常（如二尖瓣反流）的敏感性。
