Askmark H, Aquilonius S M, Gillberg P G, Liedholm L J, Stålberg E, Wuopio R
University Hospital, Uppsala, Sweden.
J Neurol Neurosurg Psychiatry. 1993 Feb;56(2):197-200. doi: 10.1136/jnnp.56.2.197.
Assuming the presence of glutamate-induced neurotoxicity in amyotrophic lateral sclerosis 14 patients were treated with dextromethorphan, an N-methyl-D-aspartate receptor antagonist. The patients were treated with 150 mg dextromethorphan or placebo daily for 12 weeks in a double-blind crossover trial, with a wash out period of 4 weeks between the two treatment periods. Thereafter the surviving patients were treated with 300 mg dextromethorphan daily for up to 6 months in an open trial. No positive effects on clinical or neurophysiological parameters (relative number of axons, and compound muscle action potentials in the abductor digiti minimi muscle) were observed either in the double-blind trial or in the open trial.
假设肌萎缩侧索硬化症存在谷氨酸诱导的神经毒性，14名患者接受了N-甲基-D-天冬氨酸受体拮抗剂右美沙芬治疗。在一项双盲交叉试验中，患者每天接受150毫克右美沙芬或安慰剂治疗，为期12周，两个治疗期之间有4周的洗脱期。此后，在一项开放试验中，存活的患者每天接受300毫克右美沙芬治疗，最长可达6个月。在双盲试验或开放试验中，均未观察到对临床或神经生理学参数（轴突相对数量以及小指展肌的复合肌肉动作电位）有积极影响。
