Schwalbe S L, Betts P R, Rayner P H, Rudd B T
Br Med J. 1977 Mar 12;1(6062):679-82. doi: 10.1136/bmj.1.6062.679.
Somatomedin activity was measured using an embryonic chick cartilage assay in 33 normal and short normal children, 23 children with pituitary growth hormone (GH) deficiency, 14 children with sexual precocity, and 13 children with chronic renal insufficiency. In normal children somatomedin activity correlated well with chronological age: low valles in early childhood rose to higher than adult levels at puberty. Children with GH deficiency had significantly lower activities and those with sexual precocity significantly higher activities than normal children. In all three groups somatomedin activity correlated well with bone age. In children with chornic renal insufficiency there was a significant correlation between decreasing somatomedin activity and both a reduced growth velocity and a falling glomerular filtration rate. Somatomedin activity and growth velocity were within normal limits in children with glomerular filtration rates above 30 ml/min/1-73 m2.
采用胚胎鸡软骨试验对33名正常儿童和正常矮身材儿童、23名垂体生长激素（GH）缺乏儿童、14名性早熟儿童和13名慢性肾功能不全儿童进行了生长介素活性测定。在正常儿童中，生长介素活性与实际年龄密切相关：幼儿期水平较低，青春期升至高于成人的水平。生长激素缺乏儿童的活性明显低于正常儿童，性早熟儿童的活性明显高于正常儿童。在所有三组中，生长介素活性与骨龄密切相关。在慢性肾功能不全儿童中，生长介素活性降低与生长速度减慢和肾小球滤过率下降之间存在显著相关性。肾小球滤过率高于30 ml/min/1.73 m²的儿童，其生长介素活性和生长速度在正常范围内。
