Chen C Z, Yu Y T, Song J C, Yuan P, Li T, Du Z
Institute for Molecular Biology, Nankai University, Tianjin, China.
Artif Organs. 1993 Feb;17(2):76-8. doi: 10.1111/j.1525-1594.1993.tb00416.x.
To remove bilirubin from patients with hyperbilirubinemia, nonionic macroporous adsorbent NK-110 was tailor-made from styrene and divinyl benzene at Nankai University. Five patients were perfused through shunts filled with 500 ml of the above adsorbent. After 2 h of hemoperfusion, total bilirubin decreased within the range of 22-51%. During the treatment, no noticeable changes in electrolytes, urea nitrogen, serum glutamicpyruvic transaminase (SGPT), TTT, and amino acid concentrations were observed. Platelet depletion was satisfactory. Hemoglobin, white cell count, globulin, and albumin showed no remarkable changes. The nonionic adsorbent shows a high efficacy for bilirubin removal and has a great potential for future clinical applications.
为了从高胆红素血症患者体内去除胆红素，南开大学以苯乙烯和二乙烯苯为原料特制了非离子型大孔吸附剂NK - 110。5名患者通过装有500毫升上述吸附剂的分流器进行灌注。血液灌注2小时后，总胆红素下降了22%至51%。治疗期间，未观察到电解质、尿素氮、血清谷丙转氨酶（SGPT）、TTT和氨基酸浓度有明显变化。血小板减少情况令人满意。血红蛋白、白细胞计数、球蛋白和白蛋白均无显著变化。这种非离子型吸附剂在去除胆红素方面显示出高效性，具有很大的未来临床应用潜力。
