Klein B E, Klein R, Linton K L, Franke T
Department of Ophthalmology, University of Wisconsin, Madison 53792-3220.
Am J Prev Med. 1993 Jan-Feb;9(1):27-30.
We evaluated the relationship between cigarette smoking behavior and lens opacities in cross-sectional data on 4,926 adults in Beaver Dam, Wisconsin. The frequencies of more severe levels of nuclear sclerosis increased with packyears of cigarette smoking in women and men. For women, the odds ratio (OR) associated with 10 packyears was 1.09 (confidence interval [CI] = 1.04, 1.16) and for men it was 1.09 (CI = 1.05, 1.14) after controlling for age. The frequencies of posterior subcapsular opacities also increased in both sexes with increased packyears. The OR associated with 10 packyears of cigarette smoking was 1.06 (CI = 0.98, 1.14) for women and 1.05 (CI = 1.00, 1.11) for men after controlling for age. There was no significant effect on cortical opacities. Smoking was associated with past cataract surgery. The significant relationships of smoking with lens opacities suggest an etiologic effect. If confirmed prospectively, our results would indicate another benefit of smoking cessation.
我们在威斯康星州比弗代尔姆的4926名成年人的横断面数据中评估了吸烟行为与晶状体混浊之间的关系。男性和女性中，更严重程度的核硬化频率随着吸烟包年数的增加而上升。对于女性，在控制年龄后，与10个吸烟包年相关的比值比（OR）为1.09（置信区间[CI]=1.04，1.16），对于男性，该比值比为1.09（CI=1.05，1.14）。后囊下混浊的频率在两性中也随着吸烟包年数的增加而上升。在控制年龄后，与10个吸烟包年相关的OR，女性为1.06（CI=0.98，1.14），男性为1.05（CI=1.00，1.11）。吸烟对皮质混浊没有显著影响。吸烟与既往白内障手术有关。吸烟与晶状体混浊之间的显著关系表明存在病因学效应。如果前瞻性研究得到证实，我们的结果将表明戒烟的另一个益处。
