Harvey S A, Nelson E, Haller J W, Early T S
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Biol Psychiatry. 1993 Jan 15;33(2):93-9. doi: 10.1016/0006-3223(93)90307-y.
Numerous studies have demonstrated a lateralized impairment of attention in schizophrenia. In this study, attention in schizophrenia is investigated with a task that involves centering a rod while blindfolded. Symptoms were rated on the Brief Psychiatric Rating Scale (BPRS) for each of the 20 schizophrenic subjects. The more symptomatic patients demonstrated a right-sided hemineglect compared to the less symptomatic patients (p = 0.013). Furthermore, the difference between more and less symptomatic patients was even more distinct when they were categorized by the BPRS schizophrenia subscale alone (p = 0.0025). These findings support the hypothesis that the pathophysiology of schizophrenia involves a lateralized defect in the control of attention, and that this defect is associated with the severity of symptoms. This raises the possibility that effects of neuroleptic medication may be asymmetric, which could account for some of the inconsistencies in studies of hemispheric dysfunction in schizophrenia.
大量研究表明精神分裂症患者存在注意力的单侧化损伤。在本研究中，通过一项蒙眼时使杆子居中的任务来研究精神分裂症患者的注意力。对20名精神分裂症患者使用简明精神病评定量表（BPRS）对症状进行评分。与症状较轻的患者相比，症状较重的患者表现出右侧偏侧忽视（p = 0.013）。此外，当仅根据BPRS精神分裂症分量表对症状较重和较轻的患者进行分类时，两者之间的差异更加明显（p = 0.0025）。这些发现支持了以下假设：精神分裂症的病理生理学涉及注意力控制方面的单侧化缺陷，并且这种缺陷与症状的严重程度相关。这增加了抗精神病药物作用可能不对称的可能性，这可能解释了精神分裂症半球功能障碍研究中的一些不一致之处。
