Løberg E-M, Jørgensen H A, Green M F, Rund B R, Lund A, Diseth A, Oie M, Hugdahl K
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
Acta Psychiatr Scand. 2006 Apr;113(4):322-31. doi: 10.1111/j.1600-0447.2005.00627.x.
Dichotic listening (DL) performance in schizophrenia, reflecting hemispheric asymmetry and the functional integrity of the left temporal lobe, can vary with clinical characteristics. Previous studies have not taken the co-linearity of clinical variables into account. The aim of the present study was to evaluate the roles of positive symptoms and duration of illness in DL through Structural Equation Modeling (SEM), thus allowing for complex relationships between the variables.
We pooled patients from four previous DL studies to create a heterogeneous group of 129 schizophrenic patients, all tested with a consonant-vowel syllables DL procedure that included attentional instructions.
A model where positive symptoms predicted a laterality component and duration of illness predicted an attention component in DL was confirmed.
Positive symptoms predicted reduced functional laterality, suggesting involvement of left temporal lobe language processing. Duration of illness predicted impaired attention modulation, possibly reflecting the involvement of frontotemporal networks.
精神分裂症患者的双耳分听（DL）表现反映了半球不对称性和左颞叶的功能完整性，其表现会因临床特征而异。以往的研究未考虑临床变量的共线性。本研究的目的是通过结构方程模型（SEM）评估阳性症状和病程在DL中的作用，从而考量变量之间的复杂关系。
我们汇总了之前四项DL研究中的患者，组成了一个由129名精神分裂症患者构成的异质性群体，所有患者均采用包含注意力指导语的辅音 - 元音音节DL程序进行测试。
一个阳性症状预测DL中的偏侧性成分、病程预测注意力成分的模型得到了证实。
阳性症状预示着功能偏侧性降低，提示左颞叶语言处理功能受累。病程预示着注意力调节受损，这可能反映了额颞叶网络的参与。
