急性一氧化碳中毒时的局部脑能量代谢

Regional cerebral energy metabolism in acute carbon monoxide intoxication.

作者信息

MacMillan V

出版信息

Can J Physiol Pharmacol. 1977 Feb;55(1):111-6. doi: 10.1139/y77-016.

Abstract

The regional cerebral metabolic effects of 30 min of exposure to 0.5, 1.0, 1.5, and 2.0% carbon monoxide (CO) were studied in lightly anesthetized rats by measurement of energy phosphates and glycolytic - citric acid cycle substrates in the basal ganglia, hippocampus-thalamus, and cerebellum. In all three regions 0.5 and 1.0% CO gave rise to increases in tissue lactate, but since ATP and the energy charge of the adenylate pool (ECP) remained unchanged from control, it is concluded that energy state was unaltered at these levels of CO. At 1.5% CO the basal ganglia region showed decreases in ATP and ECP, whereas these values for cerebellum and hippocampus=thalamus were unchanged from control. At 2.0% CO all areas showed decreases in APT and ECP and increases in ADP and AMP. The patterns of change in glycolytic and citric acid cycle substrates were similar in all three areas. The results indicated that the energy homeostasis of the basal ganglia is less well maintained in this form of experimental hypoxia.

摘要

通过测量基底神经节、海马 - 丘脑和小脑中的能量磷酸盐以及糖酵解 - 柠檬酸循环底物，研究了轻度麻醉的大鼠暴露于0.5%、1.0%、1.5%和2.0%一氧化碳（CO）30分钟后的局部脑代谢效应。在所有这三个区域中，0.5%和1.0%的CO会导致组织乳酸增加，但由于ATP和腺苷酸池的能荷（ECP）与对照组相比保持不变，因此得出结论，在这些CO水平下能量状态未改变。在1.5%的CO浓度下，基底神经节区域的ATP和ECP降低，而小脑和海马 - 丘脑的这些值与对照组相比未发生变化。在2.0%的CO浓度下，所有区域的ATP和ECP均降低，ADP和AMP增加。所有三个区域中糖酵解和柠檬酸循环底物的变化模式相似。结果表明，在这种实验性缺氧形式下，基底神经节的能量稳态维持得较差。