Klare I, Heier H, Claus H, Witte W
Robert Koch-Institute of the Federal Office of Health, Wernigerode, FRG.
FEMS Microbiol Lett. 1993 Jan 1;106(1):23-9. doi: 10.1111/j.1574-6968.1993.tb05930.x.
High-level resistance to glycopeptides in Enterococcus faecium is associated with an inducible 39-kDa cytoplasmic membrane protein. The present paper shows that such glycopeptide-resistant E. faecium strains can not only be isolated in a definite clinical setting but also from waste water of sewage treatment plants. Nearer characterization of these and of clinical isolates by resistance pattern, biotyping, and genotyping (DNA-fingerprinting with pulsed-field gel electrophoresis) has shown that different glycopeptide-resistant E. faecium strains have been isolated from clinical sources and from waste water.
粪肠球菌对糖肽类的高水平耐药性与一种可诱导的39 kDa细胞质膜蛋白有关。本文表明，这种耐糖肽类的粪肠球菌菌株不仅可在特定临床环境中分离得到，还可从污水处理厂的废水中分离得到。通过耐药模式、生物分型和基因分型（脉冲场凝胶电泳进行DNA指纹分析）对这些菌株以及临床分离株进行更深入的特征分析表明，已从临床来源和废水中分离出不同的耐糖肽类粪肠球菌菌株。
