Lee Y J, Pantuck C B, Pantuck E J
Department of Anesthesiology, Yonsei University College of Medicine, Seoul, Korea.
Planta Med. 1993 Feb;59(1):17-9. doi: 10.1055/s-2006-959595.
The effect of red ginseng extract on the disposition of ethanol was studied in male Fischer 344 rats. Blood was drawn from the tail vein before and at 0.5, 1, 2, 3, 4, and 5 hours after dosing rats orally with aqueous ginseng (200 mg/kg), or an equivalent volume of water, followed immediately by 50% ethanol orally (3.2 g/kg) or intraperitoneally (1.5 g/kg). When the ethanol was administered orally, the mean area under the plasma concentration-time curve (0-->5 h) of ethanol was 21.0% less in the ginseng-treated rats than in the control rats. When the ethanol was administered intraperitoneally, there was no significant difference between ginseng-treated and control rats in area under the plasma concentration-time curve. The results show that plasma levels of ethanol are lower when the ethanol is administered orally with ginseng than when it is administered alone, but that orally administered ginseng has no effect on plasma levels of ethanol administered intraperitoneally.
在雄性Fischer 344大鼠中研究了红参提取物对乙醇代谢的影响。在给大鼠口服人参水溶液（200mg/kg）或等量水后，立即经口（3.2g/kg）或腹腔注射（1.5g/kg）给予50%乙醇，于给药前及给药后0.5、1、2、3、4和5小时从尾静脉取血。当经口给予乙醇时，人参处理组大鼠乙醇的血浆浓度-时间曲线下平均面积（0→5小时）比对照组大鼠低21.0%。当腹腔注射乙醇时，人参处理组和对照组大鼠的血浆浓度-时间曲线下面积无显著差异。结果表明，与单独给予乙醇相比，乙醇与人参同时经口给药时乙醇的血浆水平较低，但经口给予人参对腹腔注射乙醇的血浆水平无影响。
