Yun T K, Yun Y S, Han I W
Cancer Detect Prev. 1983;6(6):515-25.
This investigation was carried out to evaluate the effects of ginseng in inhibition or prevention of carcinogenesis induced by various chemical carcinogens. Korean red ginseng was administered orally to the newborn mice. 9, 10-Dimethyl-1,2-benzanthracene (DMBA), urethane, and aflatoxin B1 were injected in subscapular region of ICR mice within 24 hr after birth. Controls comprised three groups of ICR newborn mice: normal, (100) ginseng, (200), and vehicle (316). The six experimental groups of ICR newborn mice comprised DMBA (101), DMBA combined with ginseng (103), urethane (94), urethane combined with ginseng (92), aflatoxin B1 (50), and aflatoxin B1 combined with ginseng (47). The mice were autopsied immediately following sacrifice. All major organs were examined grossly and weighed. Histopathological examinations were also made. In the group sacrificed at 48 weeks after the treatment with DMBA (DMBA combined with ginseng extract), the average diameter of the largest lung adenomas decreased by 23%. The incidence of diffuse pulmonary infiltration decreased by 63%, and the average lung weight of male mice decreased by 21%. In the group sacrificed at 28 weeks after the treatment (urethane combined with ginseng), there was a 22% decrease (P less than 0.05) in the incidence of lung adenoma. In the group sacrificed at 56 weeks after birth (aflatoxin B1 combined with ginseng), there were decreases in the incidence of lung adenoma (29%) and hepatoma (75%) (P less than 0.05). These findings indicate that the prolonged administration of Korean red ginseng extract inhibited the incidence and also the proliferation of tumors induced by DMBA, urethane, and aflatoxin B1.
本研究旨在评估人参对各种化学致癌物诱导的致癌作用的抑制或预防效果。给新生小鼠口服韩国红参。在出生后24小时内，将9,10 - 二甲基 - 1,2 - 苯并蒽（DMBA）、氨基甲酸乙酯和黄曲霉毒素B1注射到ICR小鼠的肩胛下区域。对照组包括三组ICR新生小鼠：正常组（100只）、人参（100mg/kg）组（100只）、人参（200mg/kg）组（100只）和赋形剂组（316只）。六组实验性ICR新生小鼠包括DMBA组（101只）、DMBA与人参联合组（103只）、氨基甲酸乙酯组（94只）、氨基甲酸乙酯与人参联合组（92只）、黄曲霉毒素B1组（50只）和黄曲霉毒素B1与人参联合组（47只）。处死小鼠后立即进行解剖。对所有主要器官进行大体检查并称重。还进行了组织病理学检查。在用DMBA处理（DMBA与人参提取物联合）48周后处死的组中，最大肺腺瘤的平均直径减小了23%。弥漫性肺浸润的发生率降低了63%，雄性小鼠的平均肺重量降低了21%。在用氨基甲酸乙酯处理（氨基甲酸乙酯与人参联合）28周后处死的组中，肺腺瘤的发生率降低了22%（P<0.05）。在出生后56周处死的组（黄曲霉毒素B1与人参联合）中，肺腺瘤的发生率（29%）和肝癌的发生率（75%）均降低（P<0.05）。这些结果表明，长期给予韩国红参提取物可抑制DMBA、氨基甲酸乙酯和黄曲霉毒素B1诱导的肿瘤的发生率及增殖。
