Cashaw J L
Veterans Affairs Medical Center, Houston, TX 77030.
Alcohol. 1993 Mar-Apr;10(2):133-8. doi: 10.1016/0741-8329(93)90092-3.
Tetrahydropapaveroline (THP), the condensation product of dopamine, and its aldehyde, dopaldehyde, have been detected in brain regions of rats after acute ethanol administration. THP levels were determined in eight brain regions of animals that received ethanol (3.0 g/kg) by intraperitoneal injection 100 or 120 minutes before decapitation. The levels of THP in two brain regions, i.e., the midbrain and striatum, were determined at time intervals ranging from 50 to 120 minutes after ethanol administration. THP was not found in brain regions of untreated animals. However, significant levels of THP were found in pooled midbrains (0.50 pmol/g tissue) and pooled hypothalami (0.20 pmol/g tissue) of animals that received ethanol 120 minutes before decapitation. Most brain regions had detectable levels of THP 100 minutes after the animals received ethanol and the striatum contained the highest concentration of the alkaloid. The concentration of THP in striata tissue of rats at 50, 70, 90, or 100 minutes after ethanol administration were 0.33, 0.38, 0.33, and 0.33 pmol/g tissue, respectively. These results demonstrate that THP can be detected in specific brain regions of the rat after acute ethanol administration.
四氢罂粟碱（THP）是多巴胺的缩合产物，其醛类物质多巴胺醛，在大鼠急性乙醇给药后的脑区中被检测到。在断头前100或120分钟通过腹腔注射给予乙醇（3.0 g/kg）的动物的八个脑区中测定了THP水平。在乙醇给药后50至120分钟的时间间隔内测定了两个脑区即中脑和纹状体中的THP水平。在未处理动物的脑区中未发现THP。然而，在断头前120分钟接受乙醇的动物的合并中脑（0.50 pmol/g组织）和合并下丘脑（0.20 pmol/g组织）中发现了显著水平的THP。大多数脑区在动物接受乙醇100分钟后有可检测到的THP水平，并且纹状体中该生物碱的浓度最高。乙醇给药后50、70、90或100分钟时大鼠纹状体组织中THP的浓度分别为0.33、0.38、0.33和0.33 pmol/g组织。这些结果表明，急性乙醇给药后可在大鼠的特定脑区中检测到THP。
