Tsujii H, Kamada T, Arimoto T, Mizoe J, Shirato H, Matsuoka Y, Irie G
Cancer. 1986 Jun 15;57(12):2261-6. doi: 10.1002/1097-0142(19860615)57:12<2261::aid-cncr2820571204>3.0.co;2-x.
From 1971 to 1983, a total of 208 patients with maxillary sinus carcinomas were treated at Department of Radiology, Hokkaido University School of Medicine, 38 by Method I (radiation + surgery + intraarterial 5-fluorouracil [5-Fu] infusion), and 170 by Method II (radiation + surgery). Radiation doses ranged from 30 to 50 Gy over 3 to 5 weeks in Method I and 52 to 58 Gy over 4 weeks in Method II. Overall actuarial survival rate at 5 years was 45.6%. No statistical difference in survival rates was found between Method I and Method II. With respect to T stage, absolute 5-year survival rates were 100% (4/4) for T2, 49.5% (52/105) for T3, and 24.4% (11/45) for T4. From our data, no advantage in the use of intra-arterial 5-Fu infusion was demonstrated; the local failures in Method I developed earlier and more frequently than in Method II. The ultimate failures for all patients were 46.8%. Since 1980 when treatment planning by using computerized tomography scans and immobilization device was initiated, improvement in survival rate while reducing an incidence of eye complications has been accomplished.
1971年至1983年期间，北海道大学医学院放射科共收治了208例上颌窦癌患者，其中38例采用方法I（放疗+手术+动脉内输注5-氟尿嘧啶[5-Fu]）治疗，170例采用方法II（放疗+手术）治疗。方法I的放疗剂量在3至5周内为30至50 Gy，方法II在4周内为52至58 Gy。5年的总精算生存率为45.6%。方法I和方法II的生存率无统计学差异。就T分期而言，T2期的5年绝对生存率为100%（4/4），T3期为49.5%（52/105），T4期为24.4%（11/45）。根据我们的数据，未证明动脉内输注5-Fu有优势；方法I的局部失败比方法II出现得更早且更频繁。所有患者的最终失败率为46.8%。自1980年开始使用计算机断层扫描和固定装置进行治疗计划以来，在提高生存率的同时降低了眼部并发症的发生率。
