Müller F, Frøland S S, Brandtzaeg P, Fagerhol M K
Kaptein W. Wilhelmsen og frues Institute of Bacteriology, University of Oslo, National Hospital, Norway.
Clin Infect Dis. 1993 Feb;16(2):301-2. doi: 10.1093/clind/16.2.301.
The level of the antifungal leukocyte protein calprotectin was determined in parotid saliva from 44 individuals with infection due to human immunodeficiency virus (HIV) and 19 healthy HIV-seronegative controls. Nine of the HIV-infected subjects suffered from oral candidiasis. Similar calprotectin levels were found in subjects with HIV infection as a whole group and in controls. When HIV-infected individuals with or without oral candidiasis were compared, the calprotectin level was significantly lower in the former group (67 micrograms/L vs. 216 micrograms/L). We suggest that calprotectin may play a role in the defense against oral candidal infections in HIV-infected patients, although several other antimicrobial factors also are probably operative.
在44例人类免疫缺陷病毒（HIV）感染患者和19名健康的HIV血清阴性对照者的腮腺唾液中测定了抗真菌白细胞蛋白钙卫蛋白的水平。9名HIV感染受试者患有口腔念珠菌病。HIV感染患者作为一个整体组与对照组的钙卫蛋白水平相似。当比较有或没有口腔念珠菌病的HIV感染个体时，前一组的钙卫蛋白水平显著较低（67微克/升对216微克/升）。我们认为钙卫蛋白可能在HIV感染患者抵御口腔念珠菌感染中发挥作用，尽管可能还有其他几种抗菌因子也在起作用。
