Dyke G W, Craven J L, Hall R, Garner R C
Jack Birch Unit for Environmental Carcinogenesis, Department of Biology, University of York, UK.
Cancer Lett. 1993 Feb;68(2-3):169-76. doi: 10.1016/0304-3835(93)90143-w.
The activity of the DNA repair enzyme O6-alkyltransferase has been studied in a series of stomachs with abnormal gastric mucosa and the activities found compared with those in normal stomachs. Enzyme activities found in stomachs with the macroscopic abnormalities of gastric ulcer, duodenal ulcer or gastric cancer were not significantly different from normal. In those stomachs where there was histological evidence of chronic atrophic gastritis or intestinal metaplasia however enzyme activities (mean 398 fmole/mg) were significantly higher than normal (mean activity 228 fmole/mg activity P < 0.001). We speculate that the conditions which stimulate these histological changes also give rise to induction of O6-alkyltransferase.
在一系列胃黏膜异常的胃部组织中研究了DNA修复酶O6-烷基转移酶的活性，并将其与正常胃部组织中的活性进行了比较。在患有胃溃疡、十二指肠溃疡或胃癌等宏观异常的胃部组织中发现的酶活性与正常情况没有显著差异。然而，在那些有慢性萎缩性胃炎或肠化生组织学证据的胃部组织中，酶活性（平均398飞摩尔/毫克）显著高于正常水平（平均活性228飞摩尔/毫克，P<0.001）。我们推测，刺激这些组织学变化的条件也会导致O6-烷基转移酶的诱导。
