Saugstad O D, Ostrem T
Eur Surg Res. 1977;9(1):48-56. doi: 10.1159/000127924.
The plasma hypoxanthine concentrations increased during hemorrhagic hypotension in dogs. A venous-arterial hypoxanthine difference was found indicating metabolism of hypoxanthine in the lungs. A maximal hypoxanthine level was found during the hypotension, then the level decreased. This probably reflects peripheral vasoconstriction. During reinfusion of the blood, a new hypoxanthine peak was observed. The urate levels also increased during the hypotension. An arterial venous difference was found. This probably illustrates that hypoxanthine is metabolized to urate in the lungs. It is concluded that the increase of plasma hypoxanthine concentrations might reflect tissue hypoxia.
犬失血性低血压期间血浆次黄嘌呤浓度升高。发现存在静脉 - 动脉次黄嘌呤差值，表明肺内有次黄嘌呤代谢。低血压期间发现次黄嘌呤水平达到最高，随后下降。这可能反映了外周血管收缩。在输血期间，观察到一个新的次黄嘌呤峰值。低血压期间尿酸水平也升高。发现存在动静脉差值。这可能说明次黄嘌呤在肺内代谢为尿酸。得出结论，血浆次黄嘌呤浓度升高可能反映组织缺氧。
