Sugimoto T, Wakizono S, Uemura T, Tsuneyoshi M, Enjoji M
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Laryngol Otol. 1993 Jan;107(1):69-74. doi: 10.1017/s0022215100122194.
A rare case of a 71-year-old man with malignant oncocytoma is presented. The tumour was found in the left parotid region with enlarged lymph nodes in the neck. The resected parotid mass consisted of three discrete nodules, each histologically characterized by a uniform proliferation of oncocytic tumour cells. The patient underwent repeated operations for recurrences and metastases, and eventually died of acute pneumonia 18 months after the first admission. Metastases to the lymph nodes, ribs, spine and liver had been clinically pointed out. Immunohistochemically, the tumour cells were positive for alpha-1-antitrypsin, alpha-1-antichymotrypsin, lactoferrin, secretory component and carcinoembryonic antigen (CEA), while they were negative for S-100 protein and HHF35 (muscle specific actin). Ultrastructural pictures disclosed numerous mitochondria in the cytoplasm of the tumour cells, revealing neither myofibrils nor secretory granules. These findings therefore support the concept that this tumour is of a glandular epithelial origin.
本文报告了一例71岁男性恶性嗜酸性细胞瘤的罕见病例。肿瘤位于左侧腮腺区，颈部淋巴结肿大。切除的腮腺肿物由三个不连续的结节组成，每个结节在组织学上的特征为嗜酸性肿瘤细胞的均匀增殖。患者因复发和转移接受了多次手术，最终在首次入院18个月后死于急性肺炎。临床上已指出有淋巴结、肋骨、脊柱和肝脏转移。免疫组织化学检查显示，肿瘤细胞α-1抗胰蛋白酶、α-1抗糜蛋白酶、乳铁蛋白、分泌成分和癌胚抗原（CEA）呈阳性，而S-100蛋白和HHF35（肌肉特异性肌动蛋白）呈阴性。超微结构图片显示肿瘤细胞胞质内有大量线粒体，未见肌原纤维和分泌颗粒。因此，这些发现支持该肿瘤起源于腺上皮的概念。
