Zhivotovsky L A, Feldman M W
Institute of General Genetics, USSR Academy of Sciences, Moscow, Russia.
J Math Biol. 1993;31(2):177-88. doi: 10.1007/BF00171225.
A new selectively neutral mutation occurs in a multilocus genetic background that has achieved a stable equilibrium at which there is a linkage disequilibrium. Perturbation techniques are applied to an extension of the branching process formulation of Fisher in order to address the question of extinction probabilities. We show that under appropriate conditions the probability of extinction of the new mutant is increased by the existence of linkage disequilibrium in the genetic background.
一个新的选择性中性突变出现在一个多基因座遗传背景中，该背景已达到稳定平衡，此时存在连锁不平衡。为了解决灭绝概率问题，将微扰技术应用于费舍尔分支过程公式的扩展。我们表明，在适当条件下，遗传背景中连锁不平衡的存在会增加新突变体的灭绝概率。
