Yefenof E, Picker L J, Scheuermann R H, Tucker T F, Vitetta E S, Uhr J W
Lautenberg Center of Immunology, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1829-33. doi: 10.1073/pnas.90.5.1829.
"Tumor dormancy" is an operational term used to describe a prolonged quiescent state in which tumor cells are present, but tumor progression is not clinically apparent. Although clinical examples of tumor dormancy abound, little is known regarding the mechanisms underlying this state. Here we utilize an antibody-induced dormancy model of an aggressive murine B-cell lymphoma (BCL1) and show that the induction of the dormant state is accompanied by dramatic changes in tumor cell morphology and cell cycle status. These data indicate the feasibility of altering the malignant phenotype of transformed cells by specific signals originating at the cell surface, and they suggest new opportunities for therapeutic intervention in cancer.
“肿瘤休眠”是一个实用术语，用于描述肿瘤细胞存在但肿瘤进展在临床上不明显的长期静止状态。尽管肿瘤休眠的临床实例比比皆是，但对于这种状态背后的机制却知之甚少。在这里，我们利用一种侵袭性小鼠B细胞淋巴瘤（BCL1）的抗体诱导休眠模型，表明休眠状态的诱导伴随着肿瘤细胞形态和细胞周期状态的显著变化。这些数据表明通过源自细胞表面的特定信号改变转化细胞恶性表型的可行性，并为癌症治疗干预提供了新机会。
