Helmers K F, Krantz D S, Howell R H, Klein J, Bairey C N, Rozanski A
Department of Medical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799.
Psychosom Med. 1993 Jan-Feb;55(1):29-36. doi: 10.1097/00006842-199301000-00006.
Two studies assess relationships of hostility to extent and severity of exercise-induced cardiac ischemia and daily life ischemia in patients with coronary artery disease (CAD). CAD patients (N = 80) who underwent exercise tomographic thallium testing to assess myocardial perfusion completed the Cook-Medley Hostility Inventory (Ho). A Composite Hostility (Chost) score obtained from the Ho scale was also used. Statistically controlling for the effects of gender in the full sample (N = 80), Chost was positively correlated with severity of perfusion defects (r = 0.22, p < 0.05). This relationship was nonsignificant in the 63 male patients, but was significant among women (N = 17, r = 0.42, p < 0.05) and among middle-aged men (less than 60 years, N = 17, r = 0.55, p < 0.05). In an overlapping sample of 42 CAD patients with ischemia (ST-segment depression > or = 1 mm) during 24 to 48 hours of ambulatory electrocardiographic monitoring, after controlling for gender, both Ho and Chost were positively correlated with total minutes of ischemia (r = 0.28 and r = 0.29, respectively, p < 0.05). In addition, there was a significant gender x hostility interaction, with stronger relationships with hostility evident for women. Results from these two studies indicate that in patients with coronary artery disease, hostility traits are significantly correlated with extent of daily life ischemia and with severity of exercise-induced myocardial ischemia. These relationships appear to be significant among female and middle aged male patients, but may be less evident among older male patients.
两项研究评估了敌意与冠状动脉疾病（CAD）患者运动诱发的心脏缺血程度和严重程度以及日常生活缺血之间的关系。接受运动断层心肌灌注铊扫描检测的CAD患者（N = 80）完成了库克-梅德利敌意量表（Ho）。还使用了从Ho量表得出的综合敌意（Chost）得分。在整个样本（N = 80）中对性别影响进行统计学控制后，Chost与灌注缺损严重程度呈正相关（r = 0.22，p < 0.05）。这种关系在63名男性患者中不显著，但在女性患者（N = 17，r = 0.42，p < 0.05）和中年男性患者（小于60岁，N = 17，r = 0.55，p < 0.05）中显著。在42名动态心电图监测24至48小时期间出现缺血（ST段压低≥1mm）的CAD患者的重叠样本中，在控制性别后，Ho和Chost均与缺血总分钟数呈正相关（分别为r = 0.28和r = 0.29，p < 0.05）。此外，存在显著的性别×敌意交互作用，女性与敌意的关系更明显。这两项研究的结果表明，在冠状动脉疾病患者中，敌意特质与日常生活缺血程度以及运动诱发的心肌缺血严重程度显著相关。这些关系在女性和中年男性患者中似乎显著，但在老年男性患者中可能不太明显。
