Kleinman H K, Weeks B S, Schnaper H W, Kibbey M C, Yamamura K, Grant D S
Laboratory of Developmental Biology, National Institute for Dental Research, National Institutes of Health, Bethesda, Maryland 20892.
Vitam Horm. 1993;47:161-86. doi: 10.1016/s0083-6729(08)60446-x.
Laminins are a family of basement membrane-derived glycoproteins that are very biologically active with a number of diverse cell types. The response of the cells is dependent on the cell type and various cell-specific intracellular events are activated. Multiple active sites on laminin and cellular receptors have been described. Both laminin and the synthetic peptides that define the active sites may have important clinical uses. For example, the neurite-promoting peptides may be useful in vivo in regeneration studies because of their potent activity with neural cells and their lack of antigenicity. Also, peptides, such as YIGSR, that inhibit angiogenesis are potentially useful for treating the vascularization of the eye that occurs in conditions such as diabetes mellitus. Likewise, the angiogenic peptide SIKVAV, because of its role in endothelial cell block vessel formation, may be useful for treating ischemia. The recent progress that has been made in characterizing basic mechanisms of action of laminin has laid the groundwork for more direct studies of its clinical relevance.
层粘连蛋白是一族源自基底膜的糖蛋白，对多种不同类型的细胞具有很强的生物活性。细胞的反应取决于细胞类型，并且会激活各种细胞特异性的细胞内事件。层粘连蛋白和细胞受体上的多个活性位点已被描述。层粘连蛋白以及定义这些活性位点的合成肽都可能具有重要的临床用途。例如，促神经突生长肽因其对神经细胞的强大活性以及缺乏抗原性，在体内再生研究中可能会有用。此外，像YIGSR这样抑制血管生成的肽，对于治疗糖尿病等病症中出现的眼部血管化可能具有潜在用途。同样，血管生成肽SIKVAV由于其在内皮细胞阻塞血管形成中的作用，可能对治疗缺血有用。最近在表征层粘连蛋白基本作用机制方面取得的进展，为更直接研究其临床相关性奠定了基础。
