Kurane I, Innis B L, Nimmannitya S, Nisalak A, Meager A, Ennis F A
Department of Medicine, University of Massachusetts Medical Center, Worcester.
Am J Trop Med Hyg. 1993 Feb;48(2):222-9. doi: 10.4269/ajtmh.1993.48.222.
We measured the levels of interferon alpha (IFN alpha) in the sera of Thai children hospitalized with dengue hemorrhagic fever (DHF) or dengue fever (DF) to examine the role of IFN alpha in dengue virus infections of humans. The percentage of patients who had detectable levels of IFN alpha (> or = 3 U/ml) was higher in patients with DHF (80%, P < 0.001) and in patients with DF (60%, P < 0.001) than in healthy Thai children (7%). The levels of IFN alpha were higher in patients with DHF and in patients with DF on the first few days after the onset of fever than in healthy Thai children. The average levels of IFN alpha in patients with DHF were high two days before defervescence, decreasing gradually until the day of defervescence. There was a subset of patients with DHF who had increasing levels of IFN alpha after defervescence. However, the levels of IFN alpha in patients with DF were not high after fever subsided. The levels of IFN alpha were not different among children with DHF grades 1, 2 and 3. Among patients with DHF, T lymphocytes were activated to a higher degree in high IFN alpha producers than in low IFN alpha producers. These results indicate that similarly high levels of IFN alpha are produced in vivo during the acute stages of DHF and DF, and that high levels of IFN alpha remain after fever subsides in some patients with DHF, but not in patients with DF.
我们检测了因登革出血热（DHF）或登革热（DF）住院的泰国儿童血清中的α干扰素（IFNα）水平，以研究IFNα在人类登革病毒感染中的作用。可检测到IFNα水平（≥3 U/ml）的患者百分比，在DHF患者中（80%，P<0.001）和DF患者中（60%，P<0.001）高于健康泰国儿童（7%）。发热开始后头几天，DHF患者和DF患者的IFNα水平高于健康泰国儿童。DHF患者的IFNα平均水平在退热前两天较高，然后逐渐下降直至退热日。有一部分DHF患者在退热后IFNα水平升高。然而，DF患者发热消退后IFNα水平不高。1、2和3级DHF儿童的IFNα水平没有差异。在DHF患者中，高IFNα产生者的T淋巴细胞活化程度高于低IFNα产生者。这些结果表明，在DHF和DF急性期，体内产生的IFNα水平同样较高，并且在一些DHF患者中，发热消退后IFNα水平仍然较高，但DF患者并非如此。
